Increased serum uric acid (SUA) levels are commonly seen in patients with metabolic
syndrome and are widely accepted as risk factors for hypertension, gout, non-alcoholic fatty …

Accumulating evidence indicates that asymptomatic hyperuricemia is involved in the
development of hypertension and chronic kidney disease. A 2-hit model has been proposed …

The kidneys' integrative responses to heat stress aid thermoregulation, cardiovascular
control, and water and electrolyte regulation. Recent evidence suggests the kidneys are at …

Urate homeostasis in humans is a complex and highly heritable process that involves ie,
metabolic urate biosynthesis, renal urate reabsorption, as well as renal and extrarenal urate …

Cardiovascular diseases (CVD) are the leading cause of global mortality and their
pathogenesis lies mainly in the atherosclerotic process. There are close connections linking …

Introduction Hyperuricemia is an overlooked cardiovascular and renal risk factor.
Epidemiological and genetic studies have shown an independent role of uric acid in the risk …

The relationship between serum uric acid (SUA) and hypertension has been a subject of
increasing interest since the 1870 discovery by Frederick Akbar Mahomed. Several …

The loss of cognitive function in Alzheimer's disease is pathologically linked with
neurofibrillary tangles, amyloid deposition, and loss of neuronal communication. Cerebral …

Gout and hyperuricaemia are two clinical situations associated with an elevated risk of
developing cardiovascular (heart failure, myocardial infarction, stroke) and metabolic and …

The prevalence of patients with hyperuricemia or gout is increasing worldwide.
Hyperuricemia and gout are primarily attributed to genetic factors, along with lifestyle factors …