NEDDylation, a post-translational modification through three-step enzymatic cascades,
plays crucial roles in the regulation of diverse biological processes. NEDD8-activating …

Protein neddylation is a post-translational modification, and its best recognized substrates
are cullin family proteins, which are the core component of Cullin-RING ligases (CRLs) …

Protein neddylation is catalyzed by a neddylation activating enzyme (NAE, E1), an E2
conjugating enzyme, and an E3 ligase. In various types of human cancers, the neddylation …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Simple Summary Chemotherapeutic DNA-damaging agents targeting replication are widely
used but predictive rationales for drug combinations and patient selection still need clinical …

Protein neddylation, a type of post-translational modifications, involves the transfer of the
ubiquitin-like protein NEDD8 to the lysine residues of a target substrate, which is catalyzed …

NF-κB transcription factors are major drivers of tumor initiation and progression. NF-κB
signaling is constitutively activated by genetic alterations or environmental signals in many …

Immune checkpoint blockade therapy aims to activate the immune system to eliminate
cancer cells. However, clinical benefits are only recorded in a subset of patients. Here, we …

Inhibition of the NEDD8-activating enzyme (NAE), the key E1 enzyme in the neddylation
cascade, has been considered an attractive anticancer strategy with the discovery of the first …

Diabetic sensory neuropathy (DSN) is one of the most common complications of type 2
diabetes (T2D), however the molecular mechanistic association between T2D and DSN …