The emergence of phase separation as an organizing principle in bacteria
Recent investigations in bacteria suggest that membraneless organelles play a crucial role
in the subcellular organization of bacterial cells. However, the biochemical functions and …
in the subcellular organization of bacterial cells. However, the biochemical functions and …
Nuclear bodies: the emerging biophysics of nucleoplasmic phases
L Zhu, CP Brangwynne - Current opinion in cell biology, 2015 - Elsevier
The cell nucleus contains a large number of membrane-less bodies that play important roles
in the spatiotemporal regulation of gene expression. Recent work suggests that low …
in the spatiotemporal regulation of gene expression. Recent work suggests that low …
Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus
Structural maintenance of chromosomes (SMC) complexes play critical roles in chromosome
dynamics in virtually all organisms, but how they function remains poorly understood. In the …
dynamics in virtually all organisms, but how they function remains poorly understood. In the …
[HTML][HTML] ParB-type DNA segregation proteins are CTP-dependent molecular switches
M Osorio-Valeriano, F Altegoer, W Steinchen, S Urban… - Cell, 2019 - cell.com
During cell division, newly replicated DNA is actively segregated to the daughter cells. In
most bacteria, this process involves the DNA-binding protein ParB, which condenses the …
most bacteria, this process involves the DNA-binding protein ParB, which condenses the …
Dynamic ParB–DNA interactions initiate and maintain a partition condensate for bacterial chromosome segregation
In most bacteria, chromosome segregation is driven by the ParAB S system where the
CTPase protein ParB loads at the parS site to trigger the formation of a large partition …
CTPase protein ParB loads at the parS site to trigger the formation of a large partition …
ATP-driven separation of liquid phase condensates in bacteria
Liquid-liquid phase-separated (LLPS) states are key to compartmentalizing components in
the absence of membranes; however, it is unclear whether LLPS condensates are actively …
the absence of membranes; however, it is unclear whether LLPS condensates are actively …
Nucleic acids modulate liquidity and dynamics of artificial membraneless organelles
J Liu, F Zhorabek, Y Chau - ACS Macro Letters, 2022 - ACS Publications
Liquid–liquid phase separation (LLPS) emerges as a fundamental underlying mechanism
for the biological organization, especially the formation of membraneless organelles (MLOs) …
for the biological organization, especially the formation of membraneless organelles (MLOs) …
ParB proteins can bypass DNA-bound roadblocks via dimer-dimer recruitment
The ParAB S system is essential for prokaryotic chromosome segregation. After loading at
parS on the genome, ParB (partition protein B) proteins rapidly redistribute to distances of …
parS on the genome, ParB (partition protein B) proteins rapidly redistribute to distances of …
Bacterial chromosome segregation by the ParABS system
Proper chromosome segregation during cell division is essential in all domains of life. In the
majority of bacterial species, faithful chromosome segregation is mediated by the tripartite …
majority of bacterial species, faithful chromosome segregation is mediated by the tripartite …
ParB spreading requires DNA bridging
The parABS system is a widely employed mechanism for plasmid partitioning and
chromosome segregation in bacteria. ParB binds to parS sites on plasmids and …
chromosome segregation in bacteria. ParB binds to parS sites on plasmids and …