Low serum albumin levels are very common in critically ill patients, with reported incidences
as high as 40–50%. This condition appears to be associated with alterations in the degree of …

The alarming increase of resistance against multiple currently available antibiotics is leading
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …

Optimizing the prescription of antimicrobials is required to improve clinical outcome from
infections and to reduce the development of antimicrobial resistance. One such method to …

The prescription of pharmaceuticals in the critically ill is complicated by a paucity of
knowledge concerning the pharmacokinetic implications of the underlying disease state …

Vancomycin and teicoplanin are the glycopeptides currently in use for the treatment of
infections caused by invasive beta-lactam-resistant gram-positive organisms. We conducted …

Successful antibiotic therapy in the critically ill requires sufficient drug concentrations at the
site of infection that kill or suppress bacterial growth. The relationship between antibiotic …

Obesity causes a number of changes, including an increase in volume of distribution and
changes in hepatic metabolism and renal excretion. Several antibiotics have sufficient data …

Background Owing to its low risk of adverse effects, teicoplanin has been extensively used
in patients with infections caused by MRSA. To promote the better management of patients …

Background Vancomycin and teicoplanin are commonly used to treat gram‐positive
infections, particularly those caused by methicillin‐resistant Staphylococcus aureus (MRSA) …

Neutrophils play an important role in immunological function. Neutropenic patients are
vulnerable to infection, and except fever is present, inflammatory reactions are scarce in …