How to enter a bacterium: bacterial porins and the permeation of antibiotics

JD Prajapati, U Kleinekathöfer… - Chemical …, 2021 - ACS Publications
Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

Water in nanopores and biological channels: a molecular simulation perspective

CI Lynch, S Rao, MSP Sansom - Chemical reviews, 2020 - ACS Publications
This Review explores the dynamic behavior of water within nanopores and biological
channels in lipid bilayer membranes. We focus on molecular simulation studies, alongside …

Modeling and simulation of ion channels

C Maffeo, S Bhattacharya, J Yoo, D Wells… - Chemical …, 2012 - ACS Publications
Transport of ions through pores in membranes is a process of fundamental importance to
cell biology. In living organisms, such transport is facilitated by ion channels that utilize the …

Altered Antibiotic Transport in OmpC Mutants Isolated from a Series of Clinical Strains of Multi-Drug Resistant E. coli

H Lou, M Chen, SS Black, SR Bushell, M Ceccarelli… - PloS one, 2011 - journals.plos.org
Antibiotic-resistant bacteria, particularly Gram negative species, present significant health
care challenges. The permeation of antibiotics through the outer membrane is largely …

[HTML][HTML] Suppl 1: Structure, function and regulation of outer membrane proteins involved in drug transport in Enterobactericeae: the OmpF/C–TolC Case

M Masi, JM Pagès - The open microbiology journal, 2013 - ncbi.nlm.nih.gov
Antibiotic translocation across membranes of Gram-negative bacteria is a key step for the
activity on their specific intracellular targets. Resistant bacteria control their membrane …

How the physical properties of bacterial porins match environmental conditions

S Milenkovic, J Wang, S Acosta-Gutierrez… - Physical Chemistry …, 2023 - pubs.rsc.org
Transmembrane β-barrel proteins are key systems for transport phenomena in biology.
Based on their broad substrate specificity, they represent good candidates for present and …

Structural insights into outer membrane permeability of Acinetobacter baumannii

M Zahn, SP Bhamidimarri, A Baslé, M Winterhalter… - Structure, 2016 - cell.com
Bacterial resistance against antibiotics is an increasing global health problem. In Gram-
negative bacteria the low permeability of the outer membrane (OM) is a major factor …

General method to determine the flux of charged molecules through nanopores applied to β-lactamase inhibitors and OmpF

I Ghai, A Pira, MA Scorciapino, I Bodrenko… - The journal of …, 2017 - ACS Publications
A major challenge in the discovery of the new antibiotics against Gram-negative bacteria is
to achieve sufficiently fast permeation in order to avoid high doses causing toxic side effects …

High salt concentrations increase permeability through OmpC channels of Escherichia coli

S Kojima, H Nikaido - Journal of Biological Chemistry, 2014 - ASBMB
OmpF and OmpC porin channels are responsible for the passage of small hydrophilic
solutes across the outer membrane of Escherichia coli. Although these channels are two of …

Filtering with Electric Field: The Case of E. coli Porins

S Acosta-Gutierrez, MA Scorciapino… - The journal of …, 2015 - ACS Publications
Although the role of general bacterial porins is well established as main pathway for polar
antibiotics, the molecular details of their mode-of-action are still under debate. Using …