Harnessing non-destructive 3D pathology
High-throughput methods for slide-free three-dimensional (3D) pathological analyses of
whole biopsies and surgical specimens offer the promise of modernizing traditional …
whole biopsies and surgical specimens offer the promise of modernizing traditional …
Intraoperative imaging in pathology-assisted surgery
The pathological assessment of surgical specimens during surgery can reduce the
incidence of positive resection margins, which otherwise can result in additional surgeries or …
incidence of positive resection margins, which otherwise can result in additional surgeries or …
Raman-encoded molecular imaging with topically applied SERS nanoparticles for intraoperative guidance of lumpectomy
Intraoperative identification of carcinoma at lumpectomy margins would enable reduced re-
excision rates, which are currently as high as 20% to 50%. Although imaging of disease …
excision rates, which are currently as high as 20% to 50%. Although imaging of disease …
Rapid pathology of lumpectomy margins with open-top light-sheet (OTLS) microscopy
Open-top light-sheet microscopy is a technique that can potentially enable rapid ex vivo
inspection of large tissue surfaces and volumes. Here, we have optimized an open-top light …
inspection of large tissue surfaces and volumes. Here, we have optimized an open-top light …
Ex vivo microscopy: a promising next-generation digital microscopy tool for surgical pathology practice
Context.—The rapid evolution of optical imaging modalities in recent years has opened the
opportunity for ex vivo tissue imaging, which has significant implications for surgical …
opportunity for ex vivo tissue imaging, which has significant implications for surgical …
[HTML][HTML] Virtual staining of non-fixed tissue histology
Surgical pathology workflow involves multiple labor-intensive steps, such as tissue removal,
fixation, embedding, sectioning, staining, and microscopic examination. This process is time …
fixation, embedding, sectioning, staining, and microscopic examination. This process is time …
Lesion detection in women breast's dynamic contrast-enhanced magnetic resonance imaging using deep learning
Breast cancer is one of the most common cancers in women and the second foremost cause
of cancer death in women after lung cancer. Recent technological advances in breast …
of cancer death in women after lung cancer. Recent technological advances in breast …
Multiscale nonlinear microscopy and widefield white light imaging enables rapid histological imaging of surgical specimen margins
The ability to histologically assess surgical specimens in real-time is a long-standing
challenge in cancer surgery, including applications such as breast conserving therapy …
challenge in cancer surgery, including applications such as breast conserving therapy …
[HTML][HTML] Slide over: advances in slide-free optical microscopy as drivers of diagnostic pathology
Conventional analysis using clinical histopathology is based on bright-field microscopy of
thinly sliced tissue specimens. Although bright-field microscopy is a simple and robust …
thinly sliced tissue specimens. Although bright-field microscopy is a simple and robust …
Label-free optical imaging technologies for rapid translation and use during intraoperative surgical and tumor margin assessment
The biannual International Conference on Biophotonics was recently held on April 30 to May
1, 2017, in Fremantle, Western Australia. This continuing conference series brought together …
1, 2017, in Fremantle, Western Australia. This continuing conference series brought together …