Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine
The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in
organ development, epithelial homeostasis, tissue regeneration, wound healing and …
organ development, epithelial homeostasis, tissue regeneration, wound healing and …
Mechanisms of Hippo pathway regulation
The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue
growth two decades ago and has been a subject extensively studied in both Drosophila and …
growth two decades ago and has been a subject extensively studied in both Drosophila and …
The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells
J Geng, S Yu, H Zhao, X Sun, X Li, P Wang… - Nature …, 2017 - nature.com
An imbalance in the lineages of immunosuppressive regulatory T cells (Treg cells) and the
inflammatory TH17 subset of helper T cells leads to the development of autoimmune and/or …
inflammatory TH17 subset of helper T cells leads to the development of autoimmune and/or …
STRIPAK, a highly conserved signaling complex, controls multiple eukaryotic cellular and developmental processes and is linked with human diseases
U Kück, D Radchenko, I Teichert - Biological chemistry, 2019 - degruyter.com
The striatin-interacting phosphatases and kinases (STRIPAK) complex is evolutionary highly
conserved and has been structurally and functionally described in diverse lower and higher …
conserved and has been structurally and functionally described in diverse lower and higher …
The role of the Hippo pathway in the pathogenesis of inflammatory bowel disease
Z Xie, Y Wang, G Yang, J Han, L Zhu, L Li… - Cell Death & …, 2021 - nature.com
Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory disorder that
primarily comprises Crohn's disease (CD) and ulcerative colitis (UC). Owing to its increasing …
primarily comprises Crohn's disease (CD) and ulcerative colitis (UC). Owing to its increasing …
Role of Hippo signaling in regulating immunity
L Hong, X Li, D Zhou, J Geng, L Chen - Cellular & molecular …, 2018 - nature.com
The Hippo signaling pathway has been established as a key regulator of organ size control,
tumor suppression, and tissue regeneration in multiple organisms. Recently, emerging …
tumor suppression, and tissue regeneration in multiple organisms. Recently, emerging …
Hippo pathway in mammalian adaptive immune system
T Yamauchi, T Moroishi - Cells, 2019 - mdpi.com
The Hippo pathway was originally identified as an evolutionarily-conserved signaling
mechanism that contributes to the control of organ size. It was then rapidly expanded as a …
mechanism that contributes to the control of organ size. It was then rapidly expanded as a …
Yap suppresses T-cell function and infiltration in the tumor microenvironment
E Stampouloglou, N Cheng, A Federico, E Slaby… - PLoS …, 2020 - journals.plos.org
A major challenge for cancer immunotherapy is sustaining T-cell activation and recruitment
in immunosuppressive solid tumors. Here, we report that the levels of the Hippo pathway …
in immunosuppressive solid tumors. Here, we report that the levels of the Hippo pathway …
MST1/MST2 protein kinases: regulation and physiologic roles
The MST1 and MST2 protein kinases comprise the GCK-II subfamily of protein kinases. In
addition to their amino-terminal kinase catalytic domain, related to that of the …
addition to their amino-terminal kinase catalytic domain, related to that of the …