Post-surgical peritoneal scarring and key molecular mechanisms

SE Herrick, B Wilm - Biomolecules, 2021 - mdpi.com
Post-surgical adhesions are internal scar tissue and a major health and economic burden.
Adhesions affect and involve the peritoneal lining of the abdominal cavity, which consists of …

[HTML][HTML] Hippo/YAP pathway for targeted therapy

E Felley-Bosco, R Stahel - Translational lung cancer research, 2014 - ncbi.nlm.nih.gov
Malignant pleural mesothelioma (MPM) is molecularly characterized by loss of function or
mutations in the neurofibromin 2 (NF2) and the cyclin-dependent kinase inhibitor 2 genes …

How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations

H Rehrauer, L Wu, W Blum, L Pecze, T Henzi… - Oncogene, 2018 - nature.com
Chronic exposure to intraperitoneal asbestos triggered a marked response in the
mesothelium well before tumor development. Macrophages, mesothelial precursor cells …

Use of mesothelial cells and biological matrices for tissue engineering of simple epithelium surrogates

CC Lachaud, B Rodriguez-Campins… - … in bioengineering and …, 2015 - frontiersin.org
Tissue-engineering technologies have progressed rapidly through last decades resulting in
the manufacture of quite complex bioartificial tissues with potential use for human organ and …

Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection

T Kisseleva, M von Köckritz-Blickwede… - Journal of molecular …, 2011 - Springer
Bone marrow (BM)-derived fibrocytes are a population of CD45+ and collagen Type I-
expressing cells that migrate to the spleen and to target injured organs, such as skin, lungs …

Mesothelin expression remodeled the immune-matrix tumor microenvironment predicting the risk of death in patients with malignant pleural mesothelioma

AN Qualiotto, CM Baldavira, M Balancin… - Frontiers in …, 2023 - frontiersin.org
Background The combination of immunobiological agents with immune checkpoint proteins
is a promising treatment for malignant pleural mesothelioma (MPM). Mesothelin and anti-PD …

The peritoneum: health, disease, and perspectives regarding tissue engineering and cell therapies

RJFC do Amaral, KD Arcanjo, MC El-Cheikh… - Cells Tissues …, 2017 - karger.com
There are several pathologies associated with the peritoneum, such as mesothelioma and
peritonitis. Moreover, the peritoneum is widely used in ultrafiltration procedures, ie …

Mesothelial-mesenchymal transitions in embryogenesis

R Carmona, L Ariza, E Cano… - Seminars in Cell & …, 2019 - Elsevier
Most animals develop coelomic cavities lined by an epithelial cell layer called the
mesothelium. Embryonic mesothelial cells have the ability to transform into mesenchymal …

Thyroid hormone-induced expression of Foxl1 in subepithelial fibroblasts correlates with adult stem cell development during Xenopus intestinal remodeling

T Hasebe, K Fujimoto, A Ishizuya-Oka - Scientific Reports, 2020 - nature.com
In the Xenopus laevis intestine during metamorphosis, stem cells appear and generate the
adult epithelium analogous to the mammalian one. We have previously shown that …

[HTML][HTML] Single-Cell RNA Sequencing Identifies Yes-Associated Protein 1–Dependent Hepatic Mesothelial Progenitors in Fibrolamellar Carcinoma

ML Jewell, JR Gibson, CD Guy, J Hyun, K Du… - The American Journal of …, 2020 - Elsevier
Fibrolamellar carcinoma (FLC) is characterized by in-frame fusion of DnaJ heat shock
protein family (Hsp40) member B1 (DNAJB1) with protein kinase cAMP-activated catalytic …