Alternative therapeutic strategies to treat antibiotic-resistant pathogens
CR MacNair, ST Rutherford, MW Tan - Nature Reviews Microbiology, 2024 - nature.com
Resistance threatens to render antibiotics—which are essential for modern medicine—
ineffective, thus posing a threat to human health. The discovery of novel classes of …
ineffective, thus posing a threat to human health. The discovery of novel classes of …
Antibiotics and bacterial resistance in the 21st century
RJ Fair, Y Tor - Perspectives in medicinal chemistry, 2014 - journals.sagepub.com
Dangerous, antibiotic resistant bacteria have been observed with increasing frequency over
the past several decades. In this review the factors that have been linked to this …
the past several decades. In this review the factors that have been linked to this …
Antibiotic resistance in Enterobacteriaceae: mechanisms and clinical implications
J Iredell, J Brown, K Tagg - Bmj, 2016 - bmj.com
Resistance of the Enterobacteriaceae to antibiotics, especially of the β lactam type, is
increasingly dominated by the mobilization of continuously expressed single genes that …
increasingly dominated by the mobilization of continuously expressed single genes that …
Pharmacology of polymyxins: new insights into an 'old'class of antibiotics
Increasing antibiotic resistance in Gram-negative bacteria, particularly in Pseudomonas
aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae, presents a global …
aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae, presents a global …
Leaks in the pipeline: a failure analysis of gram-negative antibiotic development from 2010 to 2020
ABSTRACT The World Health Organization (WHO) has warned that our current arsenal of
antibiotics is not innovative enough to face impending infectious diseases, especially those …
antibiotics is not innovative enough to face impending infectious diseases, especially those …
Acinetobacter baumannii: evolution of antimicrobial resistance—treatment options
The first decade of the 20th century witnessed a surge in the incidence of infections due to
several highly antimicrobial-resistant bacteria in hospitals worldwide. Acinetobacter …
several highly antimicrobial-resistant bacteria in hospitals worldwide. Acinetobacter …
New antibiotics for bad bugs: where are we?
M Bassetti, M Merelli, C Temperoni… - Annals of clinical …, 2013 - Springer
Bacterial resistance to antibiotics is growing up day by day in both community and hospital
setting, with a significant impact on the mortality and morbidity rates and the financial burden …
setting, with a significant impact on the mortality and morbidity rates and the financial burden …
Nonribosomal antibacterial peptides that target multidrug-resistant bacteria
Y Liu, S Ding, J Shen, K Zhu - Natural product reports, 2019 - pubs.rsc.org
Covering: 2000 to 2018, particularly from 2010 to early 2018 The increase in the incidence
of antibiotic resistant infections is threatening to overwhelm healthcare practices worldwide …
of antibiotic resistant infections is threatening to overwhelm healthcare practices worldwide …
Recent advances and perspectives in the design and development of polymyxins
F Rabanal, Y Cajal - Natural product reports, 2017 - pubs.rsc.org
Covering: 1947-early 2017, particularly from 2005-early 2017 The rise of bacterial
pathogens with acquired resistance to almost all available antibiotics is becoming a serious …
pathogens with acquired resistance to almost all available antibiotics is becoming a serious …
Pharmacokinetics and pharmacodynamics of 'old'polymyxins: what is new?
'Old'colistin and polymyxin B are increasingly used as last-line therapy against multidrug-
resistant Gram-negative bacteria Pseudomonas aeruginosa, Acinetobacter baumannii, and …
resistant Gram-negative bacteria Pseudomonas aeruginosa, Acinetobacter baumannii, and …