Alternative therapeutic strategies to treat antibiotic-resistant pathogens

CR MacNair, ST Rutherford, MW Tan - Nature Reviews Microbiology, 2024 - nature.com
Resistance threatens to render antibiotics—which are essential for modern medicine—
ineffective, thus posing a threat to human health. The discovery of novel classes of …

Antibiotics and bacterial resistance in the 21st century

RJ Fair, Y Tor - Perspectives in medicinal chemistry, 2014 - journals.sagepub.com
Dangerous, antibiotic resistant bacteria have been observed with increasing frequency over
the past several decades. In this review the factors that have been linked to this …

Antibiotic resistance in Enterobacteriaceae: mechanisms and clinical implications

J Iredell, J Brown, K Tagg - Bmj, 2016 - bmj.com
Resistance of the Enterobacteriaceae to antibiotics, especially of the β lactam type, is
increasingly dominated by the mobilization of continuously expressed single genes that …

Pharmacology of polymyxins: new insights into an 'old'class of antibiotics

T Velkov, KD Roberts, RL Nation… - Future …, 2013 - Taylor & Francis
Increasing antibiotic resistance in Gram-negative bacteria, particularly in Pseudomonas
aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae, presents a global …

Leaks in the pipeline: a failure analysis of gram-negative antibiotic development from 2010 to 2020

NK Prasad, IB Seiple, RT Cirz… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
ABSTRACT The World Health Organization (WHO) has warned that our current arsenal of
antibiotics is not innovative enough to face impending infectious diseases, especially those …

Acinetobacter baumannii: evolution of antimicrobial resistance—treatment options

Y Doi, GL Murray, AY Peleg - Seminars in respiratory and …, 2015 - thieme-connect.com
The first decade of the 20th century witnessed a surge in the incidence of infections due to
several highly antimicrobial-resistant bacteria in hospitals worldwide. Acinetobacter …

New antibiotics for bad bugs: where are we?

M Bassetti, M Merelli, C Temperoni… - Annals of clinical …, 2013 - Springer
Bacterial resistance to antibiotics is growing up day by day in both community and hospital
setting, with a significant impact on the mortality and morbidity rates and the financial burden …

Nonribosomal antibacterial peptides that target multidrug-resistant bacteria

Y Liu, S Ding, J Shen, K Zhu - Natural product reports, 2019 - pubs.rsc.org
Covering: 2000 to 2018, particularly from 2010 to early 2018 The increase in the incidence
of antibiotic resistant infections is threatening to overwhelm healthcare practices worldwide …

Recent advances and perspectives in the design and development of polymyxins

F Rabanal, Y Cajal - Natural product reports, 2017 - pubs.rsc.org
Covering: 1947-early 2017, particularly from 2005-early 2017 The rise of bacterial
pathogens with acquired resistance to almost all available antibiotics is becoming a serious …

Pharmacokinetics and pharmacodynamics of 'old'polymyxins: what is new?

PJ Bergen, CB Landersdorfer, J Zhang, M Zhao… - … and infectious disease, 2012 - Elsevier
'Old'colistin and polymyxin B are increasingly used as last-line therapy against multidrug-
resistant Gram-negative bacteria Pseudomonas aeruginosa, Acinetobacter baumannii, and …