The cornea is the most sensitive structure in the human body. Corneal nerves adapt to
maintain transparency and contribute to corneal health by mediating tear secretion and …

The cornea consists primarily of three layers: an outer layer containing an epithelium, a
middle stromal layer consisting of a collagen-rich extracellular matrix (ECM) interspersed …

Drs. Paul L. Kaufman, Albert Alm, Leonard A Levin, Siv FE Nilsson, James Ver Hoeve, and
Samuel Wu present the 11th Edition of the classic text Adler's Physiology of the Eye …

Tissue injury may create a specific microenvironment for inducing the systemic participation
of stromal-like cells in the repair process. Here we show that substance P is an injury …

Optimal vision is contingent upon transparency of the cornea. Corneal neovascularization,
trauma and, surgical procedures such as photorefractive keratectomy and graft rejection …

The nuclear factor-κB (NF-κB) is a key transcription factor pathway that is responsible for
many key biological processes, such as inflammation, apoptosis, stress response, corneal …

A number of growth factors and their associated receptors, including epidermal growth
factor, transforming growth factor-β, keratinocyte growth factor, hepatocyte growth factor …

Fibrosis is a pathological condition that is characterized by the replacement of dead or
damaged tissue with a nonfunctional, mechanically aberrant scar, and fibrotic pathologies …

Bacterial keratitis continues to be one of the leading causes of corneal blindness in the
developed as well as the developing world, despite swift progress since the dawn of the …

Recapitulating the microstructure of the native human corneal stromal tissue is believed to
be a key feature in successfully engineering the corneal tissue. The stratified multilayered …