In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Paracetamol (acetaminophen) is the most commonly used over‐the‐counter (OTC) drug in
the world. Despite its popularity and use for many years, the safety of its application and its …

In an increasing number of states and countries, cannabis now stands poised to join alcohol
and tobacco as a legal drug. Quantifying the relative adverse and beneficial effects of …

Cannabis is the most commonly used illicit drug worldwide, with~ 5 million daily users
worldwide. Emerging evidence supports a number of associations between cannabis and …

Recent evidence suggests that neuronal plasticity plays an important role in the recovery
from depression. Antidepressant drugs and electroconvulsive shock treatment increase the …

The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …

Among the many signalling lipids, endocannabinoids are increasingly recognized for their
important roles in neuronal and glial development. Recent experimental evidence suggests …

Cannabinoids, the active components of cannabis (Cannabis sativa) extracts, have attracted
the attention of human civilizations for centuries, much earlier than the discovery and …

The roles of endocannabinoid signaling during central nervous system development are
unknown. We report that CB1 cannabinoid receptors (CB1Rs) are enriched in the axonal …

Endocannabinoids primarily influence neuronal synaptic communication within the nervous
system. To exert their function, endocannabinoids need to travel across the intercellular …