Maintaining proteome integrity is essential for long-term viability of all organisms and is
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …

Endoplasmic reticulum (ER)-associated degradation (ERAD) and the unfolded protein
response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for …

The endoplasmic reticulum (ER) and mitochondria are tightly associated with very dynamic
platforms termed mitochondria-associated membranes (MAMs). MAMs provide an excellent …

Protein homeostasis mechanisms are fundamentally important to match cellular needs and
to counteract stress conditions. A fundamental challenge is to understand how defective …

Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous
neurological disorders characterized by pathophysiologic hallmark of length-dependent …

The endoplasmic reticulum (ER) is the site of synthesis for nearly one-third of the eukaryotic
proteome and is accordingly endowed with specialized machinery to ensure that proteins …

Membrane microdomains with distinct lipid compositions, called lipid rafts, represent a
potential mechanism for compartmentalizing cellular functions within the plane of biological …

Prohibitins constitute an evolutionarily conserved and ubiquitously expressed family of
membrane proteins that are essential for cell proliferation and development in higher …

Abstract Inositol 1, 4, 5‐trisphosphate receptors (IP3Rs) are expressed in nearly all animal
cells, where they mediate the release of Ca2+ from intracellular stores. The complex spatial …

Ubiquitin ligases (E3s) embedded in the endoplasmic reticulum (ER) membrane regulate
essential cellular activities including protein quality control, calcium flux, and sterol …