Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response
DR Wang, XL Wu, YL Sun - Signal transduction and targeted therapy, 2022 - nature.com
Cancers are highly complex diseases that are characterized by not only the overgrowth of
malignant cells but also an altered immune response. The inhibition and reprogramming of …
malignant cells but also an altered immune response. The inhibition and reprogramming of …
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to
import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in …
import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in …
Organoid and spheroid tumor models: Techniques and applications
S Gunti, ATK Hoke, KP Vu, NR London Jr - Cancers, 2021 - mdpi.com
Simple Summary Cell cultures can be carried out in three dimensions (3D). Organoids and
spheroids are different 3D cell culture models that can be cultured with different techniques …
spheroids are different 3D cell culture models that can be cultured with different techniques …
Application of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer
H Zhang, C Qin, C An, X Zheng, S Wen, W Chen, X Liu… - Molecular Cancer, 2021 - Springer
Abstract The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and
Jennifer Doudna for the development of the Clustered regularly interspaced short …
Jennifer Doudna for the development of the Clustered regularly interspaced short …
Novel CRISPR–Cas systems: an updated review of the current achievements, applications, and future research perspectives
According to Darwin's theory, endless evolution leads to a revolution. One such example is
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …
Disease modelling in human organoids
MA Lancaster, M Huch - Disease models & mechanisms, 2019 - journals.biologists.com
The past decade has seen an explosion in the field of in vitro disease modelling, in
particular the development of organoids. These self-organizing tissues derived from stem …
particular the development of organoids. These self-organizing tissues derived from stem …
Liver organoids: from basic research to therapeutic applications
Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a
dish. While mouse models and cell lines have furthered our understanding of liver biology …
dish. While mouse models and cell lines have furthered our understanding of liver biology …
[PDF][PDF] CRISPR-Cas tools and their application in genetic engineering of human stem cells and organoids
CRISPR-Cas technology has revolutionized biological research and holds great therapeutic
potential. Here, we review CRISPR-Cas systems and their latest developments with an …
potential. Here, we review CRISPR-Cas systems and their latest developments with an …
Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing
CRISPR–Cas9 technology has revolutionized genome editing and is applicable to the
organoid field. However, precise integration of exogenous DNA sequences into human …
organoid field. However, precise integration of exogenous DNA sequences into human …