There has been increasing interest in pyroptosis as a novel form of pro-inflammatory
programmed cell death. The mechanism of pyroptosis is significantly different from other …

Inflammasomes have emerged as critical innate sensors of host immune that defense
against pathogen infection, metabolism syndrome, cellular stress and cancer metastasis in …

Inflammasomes, particularly the nucleotide-binding oligomerization domain, leucine-rich
repeat, and pyrin domain containing 3 (NLRP3) inflammasome, apparently serve as crucial …

The liver is an essential immunological organ due to its gatekeeper position to bypassing
antigens from the intestinal blood flow and microbial products from the intestinal …

Procyanidins, as a kind of dietary flavonoid, have excellent pharmacological properties,
such as antioxidant, antibacterial, anti-inflammatory and anti-tumor properties, and so they …

Inflammation has been known to be an important driver of fibrogenesis in the liver and onset
of hepatic fibrosis. It starts off as a process meant to protect the liver from further damage, but …

NLRP3 inflammasome is an important therapeutic target for a number of human diseases.
Herein, computationally designed series of quinazolin-4 (3 H)-ones were synthesized using …

Fuzi (Aconitum carmichaelii Debx) has been traditionally used for the treatment of ulcerative
colitis (UC) in China for thousands of years. The total alkaloids of A. carmichaelii (AAC) have …

Inflammation is a hallmark of progressive liver diseases such as chronic viral or immune-
mediated hepatitis, alcohol-associated liver disease, and NAFLD. Preclinical and clinical …

Schistosomiasis is a parasitic helminth disease that can cause severe inflammatory
pathology, leading to organ damage, in humans. During a schistosomal infection, the eggs …