Growing evidence showed the increased prevalence of cancer incidents, particularly
colorectal cancer, among type 2 diabetic mellitus patients. Antidiabetic medications such as …

Vitamin D regulates the pleiotropic effect to maintain cellular homeostasis and
epidemiological evidence establishes an association between vitamin D deficiency and …

Although effective drugs have been developed, including 5-fluorouracil (5-FU), advanced
colorectal cancer (CRC) shows low therapeutic sensitivity resulting from the development of …

Increasing interest in studying the role of vitamin D in cancer has been provided by the
scientific literature during the last years, although mixed results have been reported. Vitamin …

Vitamin D deficiency is a global health problem due to its high prevalence and its negative
consequences on musculoskeletal and extra-skeletal health. In our comparative review of …

Colorectal cancer (CRC), a common tumor, is characterized by a high mortality rate. Long
non-coding RNA maternally expressed gene 3 (MEG3) serves a regulatory role in the …

Aims This study measured the effects of 5-Fluorouracil (5-FU), calcitriol (VD 3), and/or
thymoquinone (TQ) single/dual/triple therapies on cell cycle progression, apoptosis …

Simple Summary Failure of chemotherapy is common during the treatment of colon cancer,
and there is a compelling need to develop alternative therapeutic approaches against this …

Organ-on-chip platforms provide models that allow the representation of human
physiological processes in cell-based miniaturized systems. Potential pre-clinical …

Tumor heterogeneity includes variable and fluctuating oxygen concentrations, which result
in the accumulation of hypoxic regions in most solid tumors. Tumor hypoxia leads to …