DNA-modifying enzymes participate in various genetic functions (eg, DNA replication,
repairing, and recombination) through alternating certain DNA sequence, and the …

Aplastic anemia (AA) is characterized by bone marrow (BM) hypocellularity, resulting in
peripheral cytopenias. An antigen-driven and likely auto-immune dysregulated T-cell …

Background Longitudinal studies have verified the pivotal role of mesenchymal stem/stromal
cells (MSCs) in the bone marrow microenvironment for hematopoiesis and coordinate …

Extensive research in countries with high sociodemographic indices (SDIs) to date has
shown that coronavirus disease 2019 (COVID-19) may be directly associated with more …

Eltrombopag, an FDA-approved non-peptidyl thrombopoietin receptor agonist, is clinically
used for the treatment of aplastic anemia, a disease characterized by hematopoietic stem …

Hypoplastic myelodysplastic syndrome (hMDS) and aplastic anemia (AA) are rare
hematopoietic disorders characterized by pancytopenia with hypoplastic bone marrow (BM) …

Acquired aplastic anemia (AA) is recognized as an immune-mediated disorder resulting
from active destruction of hematopoietic cells in bone marrow (BM) by effector T …

Autoimmune diseases are primary immune diseases in which autoreactive antibodies or
sensitized lymphocytes destroy and damage tissue and cellular components, resulting in …

There is growing interest in the contribution of the marrow niche to the pathogenesis of bone
marrow failure syndromes, ie, aplastic anemia (AA) and myelodysplastic syndromes (MDSs) …

Bone marrow failure (BMF) syndromes are a heterogenous group of non-malignant
hematologic diseases characterized by single-or multi-lineage cytopenia (s) with either …