In the epigenetics field, large-scale functional genomics datasets of ever-increasing size and
complexity have been produced using experimental techniques based on high-throughput …

Motivation Most existing coverage-based (epi) genomic datasets are one-dimensional, but
newer technologies probing interactions (physical, genetic, etc.) produce quantitative maps …

As the building blocks of chromatin, histones are central to establish and maintain particular
chromatin states associated with given cell fates. Importantly, histones exist as distinct …

We present HiGlass, an open source visualization tool built on web technologies that
provides a rich interface for rapid, multiplex, and multiscale navigation of 2D genomic maps …

Drosophila insulators were the first DNA elements found to regulate gene expression by
delimiting chromatin contacts. We still do not know how many of them exist and what impact …

Ependymoma is a tumor of the brain or spinal cord. The two most common and aggressive
molecular groups of ependymoma are the supratentorial ZFTA-fusion associated and the …

Background Data visualization, especially the genome track plots, is crucial for genomics
researchers to discover patterns in large-scale sequencing dataset. Although existing tools …

Regulatory networks containing enhancer-gene edges define cellular states. Multiple efforts
have revealed these networks for reference tissues and cell lines by integrating multi-omics …

Hepatocellular carcinoma (HCC) is a common disease of the digestive system with no
curative treatments. Long noncoding RNA tyrosine protein kinase transmembrane receptor 1 …

Motivation The high-throughput chromosome conformation capture (Hi-C) technique has
enabled genome-wide mapping of chromatin interactions. However, high-resolution Hi-C …