The extraordinary ability of the liver to regenerate after injury or resection has long
fascinated physicians, scientists, and lay persons. The earliest allusion to the liver's …

Adult somatic tissues have proven difficult to expand in vitro, largely because of the
complexity of recreating appropriate environmental signals in culture. We have overcome …

The diagnosis of nonalcoholic fatty liver disease and associated fibrosis is challenging given
the lack of signs, symptoms and nonexistent diagnostic test. Furthermore, follow up and …

Primary hepatocytes are a vital tool in various biomedical research disciplines, serving as an
ex vivo model for liver physiology. Obtaining high yields of viable primary mouse …

The Hippo-signaling pathway is an important regulator of cellular proliferation and organ
size. However, little is known about the role of this cascade in the control of cell fate …

Hepatic specification and functional maturation are tightly controlled throughout
development. N6-methyladenosine (m6A) is the most abundant RNA modification of …

Background & Aims Endoplasmic reticulum to nucleus signaling 1 (ERN1, also called
IRE1A) is a sensor of the unfolded protein response that is activated in the livers of patients …

Interleukin (IL)-6 is one of several proinflammatory cytokines that have been associated with
insulin resistance and type 2 diabetes. A two-to threefold elevation of circulating IL-6 has …

RNA interference (RNAi) is a powerful tool to silence gene expression post-transcriptionally.
However, its potential to treat or prevent disease remains unproven. Fas-mediated apoptosis …

Activation of 40S ribosomal protein S6 kinases (S6Ks) is mediated by anabolic signals
triggered by hormones, growth factors, and nutrients. Stimulation by any of these agents is …