Potential mechanisms of formononetin against inflammation and oxidative stress: a review

M Ding, Y Bao, H Liang, X Zhang, B Li… - Frontiers in …, 2024 - frontiersin.org
Formononetin (FMNT) is a secondary metabolite of flavonoids abundant in legumes and
graminaceous plants such as Astragalus mongholicus Bunge [Fabaceae; Astragali radix] …

[HTML][HTML] Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction

J Huang, Y Liang, L Zhou - Frontiers in Pharmacology, 2023 - frontiersin.org
The patients with kidney diseases are increasing rapidly all over the world. With the rich
abundance of mitochondria, kidney is an organ with a high consumption of energy. Hence …

Oral delivery of nerolidol alleviates cyclophosphamide-induced renal inflammation, apoptosis, and fibrosis via modulation of NF-κB/cleaved caspase-3/TGF-β …

A Iqubal, AK Najmi, S Md, HM Alkreathy, J Ali… - Drug Delivery, 2023 - Taylor & Francis
Cyclophosphamide (CP) is one of the most extensively used antineoplastic drug, but the
nephrotoxicity caused by this drug is a major limiting factor for its use. Nerolidol (NERO) is a …

[HTML][HTML] Formononetin ameliorates airway inflammation by suppressing ESR1/NLRP3/Caspase-1 signaling in asthma

L Zhang, Q Wu, Y Huang, J Zheng, S Guo… - Biomedicine & …, 2023 - Elsevier
Since inhaled glucocorticoids are the first-line treatment for asthma, asthma management
becomes extremely difficult when asthma does not react well to glucocorticoids …

Formononetin attenuates cigarette smoke‐induced COPD in mice by suppressing inflammation, endoplasmic reticulum stress, and apoptosis in bronchial epithelial …

X Li, X Jiang, R Zeng, X Lai, J Wang, H Liu… - Phytotherapy …, 2024 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a chronic, progressive, and lethal lung
disease with few treatments. Formononetin (FMN) is a clinical preparation extract with …

[HTML][HTML] Guben Xiezhuo Decoction inhibits M1 polarization through the Raf1/p-Elk1 signaling axis to attenuate renal interstitial fibrosis

Y Liu, J Wu, S Liang, J Xu, M Wei, Z Du… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Guben Xiezhuo Decoction (GBXZD) is an herbal
compound used to treat chronic kidney disease (CKD) under the guidance of traditional …

Formononetin attenuates high glucose-induced neurotoxicity by negatively regulating oxidative stress and mitochondrial dysfunction in Schwann cells via activation of …

W Jiang, T Hu, C Ye, M Hu, Q Yu, L Sun, J Liang… - Food and Chemical …, 2023 - Elsevier
High glucose induces Schwann cells death and neurotoxicity. Formononetin was originally
found in Astragalus membranaceus and showed anti-tumor and anti-neuroinflammation …

Renoprotective and oxidative stress-modulating effects of taxifolin against cadmium-induced nephrotoxicity in mice

AI Algefare - Life, 2022 - mdpi.com
Cadmium (Cd) is an inessential trace metal that accumulates in the kidney and may lead to
renal toxicity by mediating oxidative stress (OS), inflammatory reactions, and apoptosis. The …

Shenling Baizhu powder alleviates non-alcoholic fatty liver disease by modulating autophagy and energy metabolism in high-fat diet-induced rats

M Pan, Y Deng, Y Qiu, D Pi, C Zheng, Z Liang, J Zhen… - Phytomedicine, 2024 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) has emerged as a burgeoning health
problem worldwide, but no specific drug has been approved for its treatment. Shenling …

Zamzam water ameliorates gentamicin-induced testicular toxicity in a rat model via targeting sperm parameters, testicular tissue oxidative insult, inflammation …

M Taha, ST Elazab, AA Saati, GS Ahmed… - Toxics, 2022 - mdpi.com
Gentamicin is considered one of the most typical causes of testicular damage. Oxidative
stress is a significant contributor to testicular tissue damage. Zamzam water (alkaline in …