Anagen stage hair follicles (HFs) exhibit “immune privilege (IP)” from the level of the bulge
downwards to the bulb. Both passive and active IP mechanisms protect HFs from …

T cells are critical for protective immune responses to pathogens and tumors. The T-cell
receptor (TCR)–CD3 complex is composed of a diverse αβ TCR heterodimer noncovalently …

Human leukocyte antigen G (HLA-G) mediates maternal-fetal immune tolerance. It is also
considered an immune checkpoint in cancer since it may mediate immune evasion and thus …

Peptides presented on MHC I molecules allow the immune system to detect diseased cells.
The displayed peptides typically stem from proteasomal degradation of cytoplasmic proteins …

Autoimmunity is defined by the presence of antibodies and/or T cells directed against self-
components. Although of unknown etiology, autoimmunity commonly is associated with …

The increasing rate of resistance of bacterial infection against antibiotics requires next
generation approaches to fight potential pandemic spread. The development of vaccines …

The polymorphic nature and intrinsic instability of class I major histocompatibility complex
(MHC-I) and MHC-like molecules loaded with suboptimal peptides, metabolites, or …

Simple Summary The anti-TRBC1 antibody JOVI-1 has recently been identified as a flow
cytometry marker potentially useful for assessment of T-cell clonality. The aim of this study …

Major histocompatibility complex class I (MHC I) molecules present peptides on the surface
of most nucleated cells and allow the immune system to detect and eliminate infected or …

Adaptive immunity vitally depends on major histocompatibility complex class I (MHC I)
molecules loaded with peptides. Selective loading of peptides onto MHC I, referred to as …