Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …

Dopamine partial agonism and functional selectivity have been innovative strategies in the
pharmacological treatment of schizophrenia and mood disorders and have shifted the …

The dopamine D3 receptor (D3R) is a target for developing medications to treat substance
use disorders. D3R-selective compounds with high affinity and varying efficacies have been …

An increasing emphasis has been placed on the development and use of animal models of
addiction that capture defining features of human drug addiction, including escalation/binge …

Since the first experimental hint for the existence of “an actual desire or striving for the drug”
in nonhuman animals by Sidney Spragg in the late 1930s, much effort has been expended …

The purpose of this study was to determine whether the tendency to sign-track to a food cue
was predictive of rats' choice of cocaine over food. First, rats were trained on a procedure …

We have adapted a nonhuman primate model of cocaine versus food choice to the rat
species. To evaluate the procedure, we tested cocaine versus food choice under a variety of …

Drug self‐administration procedures have played a critical role in the experimental analysis
of psychoactive compounds, such as cocaine, for over 50 years. While there are numerous …

Background Preclinical drug self-administration procedures are commonly used to
investigate expression, mechanisms, and treatment of substance use disorders. New …

Ample evidence shows that the setting can control drug choices in both humans and
animals. Here we reveal in rats that a major mechanism of this control involves a regulation …