Triple-negative breast cancer (TNBC) remains the most challenging breast cancer subtype
to treat. To date, therapies directed to specific molecular targets have rarely achieved …

Myc is a nuclear transcription factor that mainly regulates cell growth, cell cycle, metabolism,
and survival. Myc family proteins contain c-Myc, n-Myc, and l-Myc. Among them, c-Myc can …

Glioma stem cells (GSC) are a subpopulation of tumor cells with special abilities to
proliferate and differentiate in gliomas. They are one of the main causes of tumor recurrence …

That cancer cells show patterns of metabolism different from normal cells has been known
for over 50 years. Yet, it is only in the past decade or so that an appreciation of the benefits …

PARP inhibitors (PARPi) benefit only a fraction of breast cancer patients. Several of those
patients exhibit intrinsic/acquired resistance mechanisms that limit efficacy of PARPi …

ERK1 and ERK2 (ERKs), two extracellular regulated kinases (ERK1/2), are evolutionary-
conserved and ubiquitous serine-threonine kinases involved in regulating cell signalling in …

Purpose Ferroptosis is a programmed form of iron-dependent cell death caused by lipid
hydroperoxide accumulation, which can be prevented by glutathione peroxidase 4 (GPx4) …

Despite improvements in overall survival, only a modest percentage of patients survives
high-risk medulloblastoma. The devastating side effects of radiation and chemotherapy …

Double strand breaks (DSBs) induced by radiotherapy are highly cytotoxic lesions, leading
to chromosomal aberrations and cell death. Ataxia-telangiectasia-mutated (ATM)-dependent …

Abstract Purpose Prostate cancer (PCa) cell radioresistance causes the failure of radiation
therapy (RT) in localized or locally advanced disease. The aberrant accumulation of c-Myc …