The two murine double minute (MDM) family members MDM2 and MDMX are at the center
of an intense clinical assessment as molecular target for the management of cancer. Indeed …

The tumor cell changes itself and its microenvironment to adapt to different situations,
including action of drugs and other agents targeting tumor control. Therefore, metabolism …

Although molecular targeted therapies have recently displayed therapeutic effects in acute
myeloid leukemia (AML), limited response and acquired resistance remain common …

Autophagy and apoptosis are functionally distinct mechanisms for cytoplasmic and cellular
turnover. While these two pathways are distinct, they can also regulate each other, and …

Since the discovery of the first MDM2 inhibitors, we have gained deeper insights into the
cellular roles of MDM2 and p53. In this review, we focus on MDM2 inhibitors that bind to the …

Members of the B-cell lymphoma 2 (BCL-2) gene family are attractive targets for cancer
therapy as they play a key role in promoting cell survival, a long-since established hallmark …

Simple Summary The activation of wild-type p53 protein in human lymphoma is a promising
therapeutic strategy. A precise interruption of a protein–protein interaction, such as the p53 …

The diverse expression patterns of the tumor suppressor p53 in cancer cells reflect the
regulatory efficiency of multiple cellular pathways. By contrast, many human tumors are …

Highlights•MDM2 and MDMX are direct, negative regulators of the tumor suppressor
p53.•MDM2 and MDMX represent important therapeutic targets in leukemias.•MDM2 …

Background: Cancer is a major global health problem with high mortality rate. Most of the
clinically used anticancer agents induce apoptosis through genotoxic stress at various …