Mitochondrial dynamics in health and disease: mechanisms and potential targets
W Chen, H Zhao, Y Li - Signal transduction and targeted therapy, 2023 - nature.com
Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …
Mitochondrial quality control mechanisms as therapeutic targets in doxorubicin-induced cardiotoxicity
Doxorubicin (DOX) is a chemotherapeutic drug that is utilized for solid tumors and
hematologic malignancies, but its clinical application is hampered by life-threatening …
hematologic malignancies, but its clinical application is hampered by life-threatening …
[HTML][HTML] Empagliflozin attenuates cardiac microvascular ischemia/reperfusion through activating the AMPKα1/ULK1/FUNDC1/mitophagy pathway
C Cai, Z Guo, X Chang, Z Li, F Wu, J He, T Cao… - Redox biology, 2022 - Elsevier
Mitophagy preserves microvascular structure and function during myocardial
ischemia/reperfusion (I/R) injury. Empagliflozin, an anti-diabetes drug, may also protect …
ischemia/reperfusion (I/R) injury. Empagliflozin, an anti-diabetes drug, may also protect …
[HTML][HTML] Coronary microvascular injury in myocardial infarction: perception and knowledge for mitochondrial quality control
X Chang, A Lochner, HH Wang, S Wang, H Zhu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Endothelial cells (ECs) constitute the innermost layer in all blood vessels to maintain the
structural integrity and microcirculation function for coronary microvasculature. Impaired …
structural integrity and microcirculation function for coronary microvasculature. Impaired …
Mitophagy in degenerative joint diseases
K Sun, X Jing, J Guo, X Yao, F Guo - Autophagy, 2021 - Taylor & Francis
Mitochondrial dysfunction is involved in aging and multiple degenerative diseases, including
intervertebral disc degeneration (IVDD) and osteoarthritis (OA). Thus, the maintenance of …
intervertebral disc degeneration (IVDD) and osteoarthritis (OA). Thus, the maintenance of …
[HTML][HTML] Mitophagy coordinates the mitochondrial unfolded protein response to attenuate inflammation-mediated myocardial injury
Mitochondrial dysfunction is a fundamental challenge in septic cardiomyopathy. Mitophagy
and the mitochondrial unfolded protein response (UPR mt) are the predominant stress …
and the mitochondrial unfolded protein response (UPR mt) are the predominant stress …
Role of mitochondrial quality surveillance in myocardial infarction: from bench to bedside
Myocardial infarction (MI) is the irreversible death of cardiomyocyte secondary to prolonged
lack of oxygen or fresh blood supply. Historically considered as merely cardiomyocyte …
lack of oxygen or fresh blood supply. Historically considered as merely cardiomyocyte …
[HTML][HTML] HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury
ZJ Fu, ZY Wang, L Xu, XH Chen, XX Li, WT Liao… - Redox biology, 2020 - Elsevier
In the present study, we hypothesized that hypoxia-inducible factor 1α (HIF-1α)-mediated
mitophagy plays a protective role in ischemia/reperfusion (I/R)-induced acute kidney injury …
mitophagy plays a protective role in ischemia/reperfusion (I/R)-induced acute kidney injury …
Exposure to imidacloprid induce oxidative stress, mitochondrial dysfunction, inflammation, apoptosis and mitophagy via NF-kappaB/JNK pathway in grass carp …
Z Miao, Z Miao, S Wang, H Wu, S Xu - Fish & Shellfish Immunology, 2022 - Elsevier
Imidacloprid (IMI) is a neonicotinoid compound widely used in agriculture production,
causing surface water pollution and threatening non-target organisms. The aim of this study …
causing surface water pollution and threatening non-target organisms. The aim of this study …
Empagliflozin attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial homeostasis
R Zou, W Shi, J Qiu, N Zhou, N Du, H Zhou… - Cardiovascular …, 2022 - Springer
Background Empagliflozin has been reported to protect endothelial cell function, regardless
of diabetes status. However, the role of empagliflozin in microvascular protection during …
of diabetes status. However, the role of empagliflozin in microvascular protection during …