Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

Doxorubicin (DOX) is a chemotherapeutic drug that is utilized for solid tumors and
hematologic malignancies, but its clinical application is hampered by life-threatening …

Mitophagy preserves microvascular structure and function during myocardial
ischemia/reperfusion (I/R) injury. Empagliflozin, an anti-diabetes drug, may also protect …

Endothelial cells (ECs) constitute the innermost layer in all blood vessels to maintain the
structural integrity and microcirculation function for coronary microvasculature. Impaired …

Mitochondrial dysfunction is involved in aging and multiple degenerative diseases, including
intervertebral disc degeneration (IVDD) and osteoarthritis (OA). Thus, the maintenance of …

Mitochondrial dysfunction is a fundamental challenge in septic cardiomyopathy. Mitophagy
and the mitochondrial unfolded protein response (UPR mt) are the predominant stress …

Myocardial infarction (MI) is the irreversible death of cardiomyocyte secondary to prolonged
lack of oxygen or fresh blood supply. Historically considered as merely cardiomyocyte …

In the present study, we hypothesized that hypoxia-inducible factor 1α (HIF-1α)-mediated
mitophagy plays a protective role in ischemia/reperfusion (I/R)-induced acute kidney injury …

Imidacloprid (IMI) is a neonicotinoid compound widely used in agriculture production,
causing surface water pollution and threatening non-target organisms. The aim of this study …

Background Empagliflozin has been reported to protect endothelial cell function, regardless
of diabetes status. However, the role of empagliflozin in microvascular protection during …