Analysis of the interplay between cell proliferation and death has been greatly advantaged
by the development of CNS slice preparations. In slices, interactions between neurons and …

Several genetic strategies for inhibiting neuronal function in mice have been described, but
no system that directly suppresses membrane excitability and is triggered by a systemically …

During postnatal cerebellar development, Purkinje cells form the most elaborate dendritic
trees among neurons in the brain, which have been of great interest to many investigators …

Cell-type-specific promoters in combination with viral vectors and gene-editing technology
permit efficient gene manipulation in specific cell populations. Cerebellar Purkinje cells play …

Inducible and reversible silencing of selected neurons in vivo is critical to understanding the
structure and dynamics of brain circuits. We have developed Molecules for Inactivation of …

Green fluorescent protein (GFP) expression was evaluated in tissues of different transgenic
rodents—Sprague-Dawley (SD) rat strain [SD-Tg (GFP) Bal], W rat strain [Wistar-TgN (CAG …

J. Neurochem.(2011) 118, 288–303. Abstract Spinocerebellar ataxia type 17 (SCA17) is an
autosomal dominant inherited disorder characterized by degeneration of spinocerebellar …

Tissue clarification has been recently proposed to allow deep tissue imaging without light
scattering. The clarification parameters are somewhat arbitrary and dependent on tissue …

Across many studies, animals with enhanced synaptic plasticity exhibit either enhanced or
impaired learning, raising a conceptual puzzle: how enhanced plasticity can yield opposite …

Myosin-1d is a monomeric actin-based motor found in a wide range of tissues, but highly
expressed in the nervous system. Previous microarray studies suggest that myosin-1d is …