Congenital PAX6-aniridia, initially characterized by the absence of the iris, has progressively
been shown to be associated with other developmental ocular abnormalities and systemic …

Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …

Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced
limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy …

Stem cell (SC) division, deployment, and differentiation are processes that contribute to
corneal epithelial renewal. Until now studying the destiny of these cells in a living mammal …

Purpose Abnormalities in the limbal niche microenvironment have been suggested to be
causally involved in aniridia-associated keratopathy (AAK), but histological analyses on the …

Nonsense mutations leading to premature stop codons are common occurring in
approximately 12% of all human genetic diseases. Thus, pharmacological nonsense …

Paired box 6 (PAX6), a nuclear transcription factor, determines the fate of limbal epithelial
progenitor cells (LEPC) and maintains epithelial cell identity. However, the expression of …

Mammalian corneal development is a multistep process, including formation of the corneal
epithelium (CE), endothelium and stroma during embryogenesis, followed by postnatal …

Maintenance of the corneal epithelium is essential for vision and is a dynamic process
incorporating constant cell production, movement and loss. Although cell-based therapies …

In order to identify reliable markers of corneal epithelial stem cells, we employed an
inducible transgenic “pulse-chase” murine model (K5Tta× TRE-H2BGFP) to localize, purify …