One of the most remarkable differences between classical engineering materials and living
matter is the ability of the latter to grow and remodel in response to diverse stimuli. The …

Soft biological tissues compromise diverse cell types and extracellular matrix constituents,
each of which can possess individual natural configurations, material properties, and rates …

The process in which locally confined epithelial malignancies progressively evolve into
invasive cancers is often promoted by unjamming, a phase transition from a solid-like to a …

Aortic dissection continues to be responsible for significant morbidity and mortality, although
recent advances in medical data assimilation and in experimental and in silico models have …

Hypertension induces significant aortic remodelling, often adaptive but sometimes not. To
identify immuno-mechanical mechanisms responsible for differential remodelling, we …

Tissue-level biomechanical properties and function derive from underlying cell signaling,
which regulates mass deposition, organization, and removal. Here, we couple two existing …

Tissue-engineered vascular grafts hold great promise in many clinical applications,
especially in pediatrics wherein growth potential is critical. A continuing challenge, however …

In vivo development of a neovessel from an implanted biodegradable polymeric scaffold
depends on a delicate balance between polymer degradation and native matrix deposition …

Aging leads to central artery stiffening and associated hemodynamic sequelae. Because
healthy arteries exhibit differential geometry, composition, and mechanical behaviors along …

Abstract Background and Objective. The prevention of ascending thoracic aortic aneurysms
(ATAAs), which affect thousands of persons every year worldwide, remains a major issue …