Metabolic hormone action in the VTA: Reward-directed behavior and mechanistic insights
CE Geisler, MR Hayes - Physiology & behavior, 2023 - Elsevier
Dysfunctional signaling in midbrain reward circuits perpetuates diseases characterized by
compulsive overconsumption of rewarding substances such as substance abuse, binge …
compulsive overconsumption of rewarding substances such as substance abuse, binge …
The intriguing ligand-dependent and ligand-independent actions of the growth hormone secretagogue receptor on reward-related behaviors
The growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor
(GPCR) highly expressed in the brain, and also in some peripheral tissues. GHSR activity is …
(GPCR) highly expressed in the brain, and also in some peripheral tissues. GHSR activity is …
Ghrelin recruits specific subsets of dopamine and GABA neurons of different ventral tegmental area sub-nuclei
Ghrelin is a stomach-derived hormone that regulates rewarding behaviors and
reinforcement by acting on the ventral tegmental area (VTA). The VTA is a complex midbrain …
reinforcement by acting on the ventral tegmental area (VTA). The VTA is a complex midbrain …
Glucagon-Like Peptide-1 (GLP-1) and 5-Hydroxytryptamine 2c (5-HT2c) Receptor Agonists in the Ventral Tegmental Area (VTA) Inhibit Ghrelin-Stimulated Appetitive …
E Howell, HM Baumgartner, LJ Zallar, JA Selva… - International Journal of …, 2019 - mdpi.com
Current literature indicates that the orexigenic peptide ghrelin increases appetitive
motivation via signaling in the mesolimbic reward system. Another gastric peptide, glucagon …
motivation via signaling in the mesolimbic reward system. Another gastric peptide, glucagon …
Contribution of growth hormone secretagogue receptor (GHSR) signaling in the ventral tegmental area (VTA) to the regulation of social motivation in male mice
SB Park, S King, D MacDonald, A Wilson… - Translational …, 2021 - nature.com
Most psychiatric disorders are characterized by deficits in the ability to interact socially with
others. Ghrelin, a hormone normally associated with the regulation of glucose utilization and …
others. Ghrelin, a hormone normally associated with the regulation of glucose utilization and …
Role of mesolimbic ghrelin in the acquisition of cocaine reward
DP Dunn, JMR Bastacky, CC Gray, S Abtahi… - Neuroscience …, 2019 - Elsevier
The present study examined the ability of ghrelin administration into either the ventral
tegmental area (VTA) or nucleus accumbens (NAc) to potentiate cocaine-induced …
tegmental area (VTA) or nucleus accumbens (NAc) to potentiate cocaine-induced …
Growth hormone secretagogue receptor in dopamine neurons controls appetitive and consummatory behaviors towards high-fat diet in ad-libitum fed mice
Growth hormone secretagogue receptor (GHSR), the receptor for ghrelin, is expressed in
key brain nuclei that regulate food intake. The dopamine (DA) pathways have long been …
key brain nuclei that regulate food intake. The dopamine (DA) pathways have long been …
Therapeutic potential of GHSR-1A antagonism in alcohol dependence, a review
Growth hormone secretagogue receptor type 1A (GHSR-1A) is a functional receptor of
orexigenic peptide ghrelin and is highly expressed in mesolimbic dopaminergic systems that …
orexigenic peptide ghrelin and is highly expressed in mesolimbic dopaminergic systems that …
[HTML][HTML] Growth Hormone Secretagogue Receptor (GHSR) Signaling in the Ventral Tegmental Area (VTA) Mediates Feeding Produced by Chronic Social Defeat …
A Smith, T Rodrigues, C Wallace, K Mezher… - Neuroscience, 2024 - Elsevier
Ghrelin, a hormone secreted by the stomach, binds to the growth hormone secretagogue
receptor (GHSR) in various brain regions to produce a number of behavioral effects that …
receptor (GHSR) in various brain regions to produce a number of behavioral effects that …
Systematic analysis of expression signatures of neuronal subpopulations in the VTA
Gene expression profiling across various brain areas at the single-cell resolution enables
the identification of molecular markers of neuronal subpopulations and comprehensive …
the identification of molecular markers of neuronal subpopulations and comprehensive …