High-risk human papillomavirus (HPV) is now recognised as the principal cause of the
increasing incidence rates of oropharyngeal squamous cell carcinoma (OPSCC) in some …

Head and neck cancer (HNC) encompasses a heterogeneous group of upper aerodigestive
tract malignancies that together comprise the seventh most common cancer worldwide, 1 …

Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for
which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 …

Some tissue types give rise to human cancers millions of times more often than other tissue
types. Although this has been recognized for more than a century, it has never been …

Background Head and neck (H&N) cancers are a heterogeneous group of malignancies,
affecting various sites, with different prognoses. The aims of this study are to analyse …

The tumor microenvironment (TME) is comprised of many different cell populations, such as
cancer-associated fibroblasts and various infiltrating immune cells, and non-cell …

Squamous cell carcinoma of the oropharynx is increasing in incidence in epidemic
proportion. This site specific increase in incidence is due to an increase in human …

Background The relative efficacy of the addition of induction chemotherapy to
chemoradiotherapy compared with chemoradiotherapy alone for patients with head and …

Background Substantial molecular evidence suggests a role for human papillomavirus
(HPV) in the pathogenesis of oropharyngeal squamous-cell carcinoma, but epidemiologic …

Mucosal human papillomaviruses (HPV) are the cause of cervical cancer and likely a subset
of head and neck squamous cell carcinomas (HNSCC), yet the global prevalence and type …