Nonsense-mediated mRNA decay (NMD) is a quality control pathway in eukaryotes that
continuously monitors mRNA transcripts to ensure truncated polypeptides are not produced …

Alternative splicing (AS) of precursor mRNA (pre-mRNA) is a cellular post-transcriptional
process that generates protein isoform diversity. Nonsense-mediated RNA decay (NMD) is …

Hypoxia induces massive changes in alternative splicing (AS) to adapt cells to the lack of
oxygen. Here, we identify the splicing factor SRSF6 as a key factor in the AS response to …

Members of the serine/arginine (SR)‐rich protein family of splicing factors play versatile
roles in RNA processing steps and are often essential for normal development. Dynamic …

The tumour suppressor p53 is activated following genotoxic stress and regulates the
expression of target genes involved in the DNA damage response (DDR). The discovery that …

Background Alternative polyadenylation (APA) refers to the regulated selection of
polyadenylation sites (PASs) in transcripts, which determines the length of their 3 …

Understanding the contribution of different molecular processes to evolution and
development is crucial for identifying the mechanisms of adaptation. Here, we used RNA …

Pharmacologic depletion of RNA-binding motif 39 (RBM39) using aryl sulfonamides
represents a promising anti-cancer therapy but requires high levels of the adaptor protein …

Members of the arginine–serine-rich protein family (SR proteins) are multifunctional RNA-
binding proteins that have emerged as key determinants for mRNP formation, identity and …

Dysregulation of pre-mRNA splicing is a common hallmark of cancer cells and it is
associated with altered expression, localization, and mutations of the components of the …