Calcineurin (PP3/PP2B) is a serine-threonine-specific phosphatase of the protein
phosphatase (PP) family (EC 3.1. 3.16), which also includes PP1, PP2A, and PP4 to-7 (25) …

The regulator of calcineurin (RCAN) was first reported as a novel gene called DSCR1,
encoded in a region termed the Down syndrome critical region (DSCR) of human …

Calcineurin (CN) is a highly conserved Ca2+–calmodulin (CaM)-dependent phosphatase
that senses Ca2+ concentrations and transduces that information into cellular responses …

* Ethel Percy Andrus Gerontology Center, and Division of Molecular & Computational
Biology, The University of Southern California, Los Angeles, California, USA;† Department …

The conserved RCN family of proteins can bind and directly regulate calcineurin, a Ca2+-
activated protein phosphatase involved in immunity, heart growth, muscle development …

The calcium-activated phosphatase calcineurin is regulated by a binding cofactor known as
modulatory calcineurin-interacting protein (MCIP) in yeast up through mammals. The …

Objectives: Cross-species conservation of sleep-like behaviors predicts the presence of
conserved molecular mechanisms underlying sleep. However, limited experimental …

We report a systematic RNA i longevity screen of 82 Caenorhabditis elegans genes selected
based on orthology to human genes differentially expressed with age. We find substantial …

Regulators of calcineurin (RCANs) in fungi and mammals have been shown to stimulate and
inhibit calcineurin signaling in vivo through direct interactions with the catalytic subunit of the …

Background An increase in intracellular calcium concentration [Ca 2+] i is one of the first
events to take place after brain ischemia. A key [Ca 2+] i-regulated signaling molecule is the …