The new antiepileptic drugs: their neuropharmacology and clinical indications

R Hanaya, K Arita - Neurologia medico-chirurgica, 2016 - jstage.jst.go.jp
The administration of antiepileptic drugs (AEDs) is the first treatment of epilepsy, one of the
most common neurological diseases. Therapeutic guidelines include newer AEDs as front …

Levetiracetam for seizure prophylaxis in neurocritical care: a systematic review and meta-analysis

T Fang, E Valdes, JA Frontera - Neurocritical care, 2022 - Springer
Background Levetiracetam is commonly used for seizure prophylaxis in patients with
intracerebral hemorrhage (ICH), traumatic brain injury (TBI), supratentorial neurosurgery …

Prophylactic antiepileptic drug administration following brain tumor resection: results of a recent AANS/CNS Section on Tumors survey

MC Dewan, RC Thompson, SN Kalkanis… - Journal of …, 2016 - thejns.org
OBJECTIVE Antiepileptic drugs (AEDs) are often administered prophylactically following
brain tumor resection. With conflicting evidence and unestablished guidelines, however, the …

Levetiracetam versus phenytoin for seizure prophylaxis during and early after craniotomy for brain tumours: a phase II prospective, randomised study

T Iuchi, K Kuwabara, M Matsumoto… - Journal of Neurology …, 2015 - jnnp.bmj.com
Objective Phenytoin (PHT) is routinely used for seizure prophylaxis in patients with brain
tumours during and after craniotomy, despite incomplete evidence. We performed a …

Cardiovascular adverse effects of phenytoin

B Guldiken, J Rémi, S Noachtar - Journal of neurology, 2016 - Springer
Phenytoin is an established drug in the treatment of acute repetitive seizures and status
epilepticus. One of its main advantages over benzodiazepines is the less sedative effect …

Epilepsy in patients with gliomas: incidence and control of seizures

T Iuchi, Y Hasegawa, K Kawasaki, T Sakaida - Journal of Clinical …, 2015 - Elsevier
Brain tumor-related epilepsy (BTRE) is a unique condition that is distinct from primary
epilepsy. The aim of this retrospective study was to clarify the epidemiology and results of …

Is there a risk of seizures in “preventive” awake surgery for incidental diffuse low-grade gliomas?

GL de Oliveira Lima, H Duffau - Journal of neurosurgery, 2015 - thejns.org
OBJECT Although a large amount of data supports resection for symptomatic diffuse low-
grade glioma (LGG), the therapeutic strategy regarding incidental LGG (ILGG) is still a matter …

[HTML][HTML] Association between survival and levetiracetam use in glioblastoma patients treated with temozolomide chemoradiotherapy

TH Roh, JH Moon, HH Park, EH Kim, CK Hong… - Scientific reports, 2020 - nature.com
This study was conducted to assess whether levetiracetam (LEV) affects the survival of
patients with glioblastoma (GBM) treated with concurrent temozolomide (TMZ) …

Efficacy and safety of prophylactic levetiracetam in supratentorial brain tumour surgery: a systematic review and meta‐analysis

C Pourzitaki, G Tsaousi, E Apostolidou… - British Journal of …, 2016 - Wiley Online Library
Aims The aim of this study was to perform an up‐to‐date systematic review and meta‐
analysis on the efficacy and safety of prophylactic administration of levetiracetam in brain …

A systematic review of perioperative seizure prophylaxis during brain tumor resection: the case for a multicenter randomized clinical trial

V Chandra, AK Rock, C Opalak, JM Stary, AP Sima… - Neurosurgical …, 2017 - thejns.org
OBJECTIVE The majority of neurosurgeons administer antiepileptic drugs (AEDs)
prophylactically for supratentorial tumor resection without clear evidence to support this …