Mechanisms of hepatic stellate cell activation
T Tsuchida, SL Friedman - Nature reviews Gastroenterology & …, 2017 - nature.com
Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …
Hepatic stellate cells as key target in liver fibrosis
T Higashi, SL Friedman, Y Hoshida - Advanced drug delivery reviews, 2017 - Elsevier
Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more
than one million deaths annually via development of cirrhosis, although no antifibrotic …
than one million deaths annually via development of cirrhosis, although no antifibrotic …
[HTML][HTML] Multi-organ proteomic landscape of COVID-19 autopsies
X Nie, L Qian, R Sun, B Huang, X Dong, Q Xiao… - Cell, 2021 - cell.com
The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …
[HTML][HTML] Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets
CY Zhang, WG Yuan, P He, JH Lei… - World journal of …, 2016 - ncbi.nlm.nih.gov
Liver fibrosis is a reversible wound-healing process aimed at maintaining organ integrity,
and presents as the critical pre-stage of liver cirrhosis, which will eventually progress to …
and presents as the critical pre-stage of liver cirrhosis, which will eventually progress to …
[HTML][HTML] Macrophage MerTK promotes liver fibrosis in nonalcoholic steatohepatitis
Nonalcoholic steatohepatitis (NASH) is emerging as a leading cause of chronic liver
disease. However, therapeutic options are limited by incomplete understanding of the …
disease. However, therapeutic options are limited by incomplete understanding of the …
Relevance of SIRT1-NF-κB axis as therapeutic target to ameliorate inflammation in liver disease
Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by
harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause …
harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause …
Natural products as a source for antifibrosis therapy
DQ Chen, YL Feng, G Cao, YY Zhao - Trends in pharmacological sciences, 2018 - cell.com
Although fibrosis is a final pathological feature of many chronic diseases, few interventions
are available that specifically target the pathogenesis of fibrosis. Natural products are …
are available that specifically target the pathogenesis of fibrosis. Natural products are …
The impact of acute or chronic alcohol intake on the NF-κB signaling pathway in alcohol-related liver disease
Ethanol misuse is frequently associated with a multitude of profound medical conditions,
contributing to health-, individual-and social-related damage. A particularly dangerous threat …
contributing to health-, individual-and social-related damage. A particularly dangerous threat …
Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice
YM Bai, F Yang, P Luo, LL Xie, JH Chen… - Military Medical …, 2023 - Springer
Abstract Background Triclosan [5-chloro-2-(2, 4-dichlorophenoxy) phenol, TCS], a common
antimicrobial additive in many personal care and health care products, is frequently detected …
antimicrobial additive in many personal care and health care products, is frequently detected …
Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction
M DeBerge, K Glinton, M Subramanian… - The Journal of …, 2021 - Am Soc Clin Investig
Tyro3, AXL, and MerTK (TAM) receptors are activated in macrophages in response to tissue
injury and as such have been proposed as therapeutic targets to promote inflammation …
injury and as such have been proposed as therapeutic targets to promote inflammation …