Nucleolus: a central hub for nuclear functions
The nucleolus is the largest and most studied nuclear body, but its role in nuclear function is
far from being comprehensively understood. Much work on the nucleolus has focused on its …
far from being comprehensively understood. Much work on the nucleolus has focused on its …
Nucleolus and nucleolar stress: from cell fate decision to disease development
Besides the canonical function in ribosome biogenesis, there have been significant recent
advances towards the fascinating roles of the nucleolus in stress response, cell destiny …
advances towards the fascinating roles of the nucleolus in stress response, cell destiny …
[HTML][HTML] Designer condensates: a toolkit for the biomolecular architect
RL Hastings, S Boeynaems - Journal of Molecular Biology, 2021 - Elsevier
Protein phase separation has emerged as a novel paradigm to explain the biogenesis of
membraneless organelles and other so-called biomolecular condensates. While the …
membraneless organelles and other so-called biomolecular condensates. While the …
Keeping up with the condensates: The retention, gain, and loss of nuclear membrane-less organelles
E Lacroix, TE Audas - Frontiers in molecular biosciences, 2022 - frontiersin.org
In recent decades, a growing number of biomolecular condensates have been identified in
eukaryotic cells. These structures form through phase separation and have been linked to a …
eukaryotic cells. These structures form through phase separation and have been linked to a …
Phase separation of a plant virus movement protein and cellular factors support virus-host interactions
SL Brown, DJ Garrison, JP May - PLoS Pathogens, 2021 - journals.plos.org
Both cellular and viral proteins can undergo phase separation and form membraneless
compartments that concentrate biomolecules. The p26 movement protein from single …
compartments that concentrate biomolecules. The p26 movement protein from single …
Nucleolar methyltransferase fibrillarin: evolution of structure and functions
MY Shubina, YR Musinova, EV Sheval - Biochemistry (Moscow), 2016 - Springer
Fibrillarin is one of the most studied nucleolar proteins. Its main functions are methylation
and processing of pre-rRNA. Fibrillarin is a highly conserved protein; however, in the course …
and processing of pre-rRNA. Fibrillarin is a highly conserved protein; however, in the course …
[HTML][HTML] ATP: Mg2+ shapes material properties of protein-RNA condensates and their partitioning of clients
Many cellular condensates are heterotypic mixtures of proteins and RNA formed in complex
environments. Magnesium ions (Mg 2+) and ATP can impact RNA folding, and local …
environments. Magnesium ions (Mg 2+) and ATP can impact RNA folding, and local …
Ribosomal stress and Tp53-mediated neuronal apoptosis in response to capsid protein of the Zika virus
LP Slomnicki, DH Chung, A Parker, T Hermann… - Scientific reports, 2017 - nature.com
We report here that in rat and human neuroprogenitor cells as well as rat embryonic cortical
neurons Zika virus (ZIKV) infection leads to ribosomal stress that is characterized by …
neurons Zika virus (ZIKV) infection leads to ribosomal stress that is characterized by …
Alternative splicing of an exitron determines the subnuclear localization of the Arabidopsis DNA glycosylase MBD4L under heat stress
Significance Statement Exonic introns (exitrons) are a poorly studied class of protein‐coding
introns within exons expected to increase genome plasticity and protein diversity. Many …
introns within exons expected to increase genome plasticity and protein diversity. Many …
Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges
Arginine-rich dipeptide repeat proteins (R-DPRs), poly (PR) and poly (GR), translated from
the hexanucleotide repeat expansion in the amyotrophic lateral sclerosis (ALS)-causative …
the hexanucleotide repeat expansion in the amyotrophic lateral sclerosis (ALS)-causative …