A critical review of LET-based intensity-modulated proton therapy plan evaluation and optimization for head and neck cancer management
In this review article, we review the 3 important aspects of linear-energy-transfer (LET) in
intensity-modulated proton therapy (IMPT) for head and neck (H&N) cancer management …
intensity-modulated proton therapy (IMPT) for head and neck (H&N) cancer management …
Relative biological effectiveness variation along monoenergetic and modulated Bragg peaks of a 62-MeV therapeutic proton beam: a preclinical assessment
P Chaudhary, TI Marshall, FM Perozziello… - International Journal of …, 2014 - Elsevier
Purpose The biological optimization of proton therapy can be achieved only through a
detailed evaluation of relative biological effectiveness (RBE) variations along the full range …
detailed evaluation of relative biological effectiveness (RBE) variations along the full range …
Analysis of the track‐ and dose‐averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code
Purpose: The motivation of this study was to find and eliminate the cause of errors in dose‐
averaged linear energy transfer (LET) calculations from therapeutic protons in small targets …
averaged linear energy transfer (LET) calculations from therapeutic protons in small targets …
[HTML][HTML] The proton-boron reaction increases the radiobiological effectiveness of clinical low-and high-energy proton beams: novel experimental evidence and …
P Bláha, C Feoli, S Agosteo, M Calvaruso… - Frontiers in …, 2021 - frontiersin.org
Protontherapy is a rapidly expanding radiotherapy modality where accelerated proton
beams are used to precisely deliver the dose to the tumor target but is generally considered …
beams are used to precisely deliver the dose to the tumor target but is generally considered …
A fast GPU‐based Monte Carlo simulation of proton transport with detailed modeling of nonelastic interactions
H Wan Chan Tseung, J Ma, C Beltran - Medical physics, 2015 - Wiley Online Library
Purpose: Very fast Monte Carlo (MC) simulations of proton transport have been
implemented recently on graphics processing units (GPUs). However, these MCs usually …
implemented recently on graphics processing units (GPUs). However, these MCs usually …
Comparison of linear energy transfer scoring techniques in Monte Carlo simulations of proton beams
DA Granville, GO Sawakuchi - Physics in Medicine & Biology, 2015 - iopscience.iop.org
Monte Carlo (MC) simulations are commonly used to study linear energy transfer (LET)
distributions in therapeutic proton beams. Various techniques have been used to score LET …
distributions in therapeutic proton beams. Various techniques have been used to score LET …
sBridging Clinical Radiotherapy and Space Radiation Therapeutics through Reactive Oxygen Species (ROS)-Triggered Delivery
C Forenzo, J Larsen - Free Radical Biology and Medicine, 2024 - Elsevier
This review explores the convergence of clinical radiotherapy and space radiation
therapeutics, focusing on ionizing radiation (IR)-generated reactive oxygen species (ROS) …
therapeutics, focusing on ionizing radiation (IR)-generated reactive oxygen species (ROS) …
A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam …
F Romano, GAP Cirrone, G Cuttone… - Physics in Medicine …, 2014 - iopscience.iop.org
Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton and
carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry …
carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry …
Evaluation of the local dose enhancement in the combination of proton therapy and nanoparticles
I Martínez‐Rovira, Y Prezado - Medical physics, 2015 - Wiley Online Library
Purpose: The outcome of radiotherapy can be further improved by combining irradiation with
dose enhancers such as high‐Z nanoparticles. Since 2004, spectacular results have been …
dose enhancers such as high‐Z nanoparticles. Since 2004, spectacular results have been …
[HTML][HTML] Tuning spatially fractionated radiotherapy dose profiles using the moiré effect
F Reaz, E Traneus, N Bassler - Scientific Reports, 2024 - nature.com
Abstract Spatially Fractionated Radiotherapy (SFRT) has demonstrated promising potential
in cancer treatment, combining the advantages of reduced post-radiation effects and …
in cancer treatment, combining the advantages of reduced post-radiation effects and …