Dual-specificity, tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases (CLKs) in human disease, an overview
MF Lindberg, L Meijer - International Journal of Molecular Sciences, 2021 - mdpi.com
Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …
DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles
Dual‐specificity tyrosine‐regulated kinases (DYRKs) comprise a family of protein kinases
within the CMGC group of the eukaryotic kinome. Members of the DYRK family are found in …
within the CMGC group of the eukaryotic kinome. Members of the DYRK family are found in …
The chromosome 21 kinase DYRK1A: emerging roles in cancer biology and potential as a therapeutic target
M Rammohan, E Harris, RS Bhansali, E Zhao, LS Li… - Oncogene, 2022 - nature.com
Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a
serine/threonine kinase that belongs to the DYRK family of proteins, a subgroup of the …
serine/threonine kinase that belongs to the DYRK family of proteins, a subgroup of the …
Activation, regulation, and inhibition of DYRK1A
Dual‐specificity tyrosine phosphorylation‐regulated kinase 1A (DYRK1A) is a protein kinase
with diverse functions in neuronal development and adult brain physiology. Higher than …
with diverse functions in neuronal development and adult brain physiology. Higher than …
The DYRK family of kinases in cancer: molecular functions and therapeutic opportunities
DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …
Salmonella effector SteE converts the mammalian serine/threonine kinase GSK3 into a tyrosine kinase to direct macrophage polarization
I Panagi, E Jennings, J Zeng, RA Günster, CD Stones… - Cell host & …, 2020 - cell.com
Many Gram-negative bacterial pathogens antagonize anti-bacterial immunity through
translocated effector proteins that inhibit pro-inflammatory signaling. In addition, the …
translocated effector proteins that inhibit pro-inflammatory signaling. In addition, the …
Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition
M Soundararajan, AK Roos, P Savitsky… - Structure, 2013 - cell.com
Summary Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinases (DYRKs) play key
roles in brain development, regulation of splicing, and apoptosis, and are potential drug …
roles in brain development, regulation of splicing, and apoptosis, and are potential drug …
DYRK1A: a down syndrome-related dual protein kinase with a versatile role in tumorigenesis
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a dual kinase
that can phosphorylate its own activation loop on tyrosine residue and phosphorylate its …
that can phosphorylate its own activation loop on tyrosine residue and phosphorylate its …
Dyrk1a from Gene Function in Development and Physiology to Dosage Correction across Life Span in Down Syndrome
H Atas-Ozcan, V Brault, A Duchon, Y Herault - Genes, 2021 - mdpi.com
Down syndrome is the main cause of intellectual disabilities with a large set of comorbidities
from developmental origins but also that appeared across life span. Investigation of the …
from developmental origins but also that appeared across life span. Investigation of the …
A novel CDC25A/DYRK2 regulatory switch modulates cell cycle and survival
M Lara-Chica, A Correa-Sáez… - Cell Death & …, 2022 - nature.com
The cell division cycle 25A (CDC25A) phosphatase is a key regulator of cell cycle
progression that acts on the phosphorylation status of Cyclin–Cyclin-dependent kinase …
progression that acts on the phosphorylation status of Cyclin–Cyclin-dependent kinase …