The mouse as a model for human biology: a resource guide for complex trait analysis
The mouse has been a powerful force in elucidating the genetic basis of human physiology
and pathophysiology. From its beginnings as the model organism for cancer research and …
and pathophysiology. From its beginnings as the model organism for cancer research and …
[HTML][HTML] Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm
Period determination in the mammalian circadian clock involves the turnover rate of the
repressors CRY and PER. We show that CRY ubiquitination engages two competing E3 …
repressors CRY and PER. We show that CRY ubiquitination engages two competing E3 …
A high-resolution association mapping panel for the dissection of complex traits in mice
Systems genetics relies on common genetic variants to elucidate biologic networks
contributing to complex disease-related phenotypes. Mice are ideal model organisms for …
contributing to complex disease-related phenotypes. Mice are ideal model organisms for …
Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling
KF Liem Jr, M He, PJR Ocbina… - Proceedings of the …, 2009 - National Acad Sciences
Mammalian Sonic hedgehog (Shh) signaling is essential for embryonic development and
stem cell maintenance and has critical roles in tumorigenesis. Although core components of …
stem cell maintenance and has critical roles in tumorigenesis. Although core components of …
THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
PV Tran, CJ Haycraft, TY Besschetnova… - Nature …, 2008 - nature.com
Abstract Characterization of previously described intraflagellar transport (IFT) mouse
mutants has led to the proposition that normal primary cilia are required for mammalian cells …
mutants has led to the proposition that normal primary cilia are required for mammalian cells …
The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking
KF Liem Jr, A Ashe, M He, P Satir, J Moran… - Journal of Cell …, 2012 - rupress.org
Two intraflagellar transport (IFT) complexes, IFT-A and IFT-B, build and maintain primary
cilia and are required for activity of the Sonic hedgehog (Shh) pathway. A weak allele of the …
cilia and are required for activity of the Sonic hedgehog (Shh) pathway. A weak allele of the …
A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome
CM Buchovecky, SD Turley, HM Brown, SM Kyle… - Nature …, 2013 - nature.com
Mutations in MECP2, encoding methyl CpG-binding protein 2, cause Rett syndrome, the
most severe autism spectrum disorder. Re-expressing Mecp2 in symptomatic Mecp2-null …
most severe autism spectrum disorder. Re-expressing Mecp2 in symptomatic Mecp2-null …
A high-resolution single nucleotide polymorphism genetic map of the mouse genome
High-resolution genetic maps are required for mapping complex traits and for the study of
recombination. We report the highest density genetic map yet created for any organism …
recombination. We report the highest density genetic map yet created for any organism …
Histocompatible embryonic stem cells by parthenogenesis
Genetically matched pluripotent embryonic stem (ES) cells generated via nuclear transfer or
parthenogenesis (pES cells) are a potential source of histocompatible cells and tissues for …
parthenogenesis (pES cells) are a potential source of histocompatible cells and tissues for …
Genetic variation and population substructure in outbred CD-1 mice: implications for genome-wide association studies
Outbred laboratory mouse populations are widely used in biomedical research. Since little is
known about the degree of genetic variation present in these populations, they are not …
known about the degree of genetic variation present in these populations, they are not …