Membrane transporters in the bioproduction of organic acids: state of the art and future perspectives for industrial applications

I Soares-Silva, D Ribas, M Sousa-Silva… - FEMS microbiology …, 2020 - academic.oup.com
Organic acids such as monocarboxylic acids, dicarboxylic acids or even more complex
molecules such as sugar acids, have displayed great applicability in the industry as these …

General mechanisms of weak acid-tolerance and current strategies for the development of tolerant yeasts

M Li, Y Chu, X Dong, H Ji - World Journal of Microbiology and …, 2024 - Springer
Yeast cells are often subjected to various types of weak acid stress in the process of
industrial production, food processing, and preservation, resulting in growth inhibition and …

Dissecting key residues of a C4-dicarboxylic acid transporter to accelerate malate export in Myceliophthora

T Wu, Y Wang, J Li, C Tian - Applied Microbiology and Biotechnology, 2023 - Springer
Efficient transporters are necessary for high concentration and purity of desired products
during industrial production. In this study, we explored the mechanism of substrate transport …

Expanding the Knowledge on the Skillful Yeast Cyberlindnera jadinii

M Sousa-Silva, D Vieira, P Soares, M Casal… - Journal of Fungi, 2021 - mdpi.com
Cyberlindnera jadinii is widely used as a source of single-cell protein and is known for its
ability to synthesize a great variety of valuable compounds for the food and pharmaceutical …

Carboxylic Acid Transporters in Candida Pathogenesis

R Alves, M Sousa-Silva, D Vieira, P Soares, Y Chebaro… - MBio, 2020 - Am Soc Microbiol
Opportunistic pathogens such as Candida species can use carboxylic acids, like acetate
and lactate, to survive and successfully thrive in different environmental niches. These …

The acetate uptake transporter family motif “NPAPLGL (M/S)” is essential for substrate uptake

D Ribas, I Soares-Silva, D Vieira, M Sousa-Silva… - Fungal Genetics and …, 2019 - Elsevier
Organic acids are recognized as one of the most prevalent compounds in ecosystems, thus
the transport and assimilation of these molecules represent an adaptive advantage for …

Ancestral function and diversification of a horizontally acquired oomycete carboxylic acid transporter

FR Savory, DS Milner, DC Miles… - Molecular Biology and …, 2018 - academic.oup.com
Horizontal gene transfer (HGT) can equip organisms with novel genes, expanding the
repertoire of genetic material available for evolutionary innovation and allowing recipient …

Yeast as a tool to express sugar acid transporters with biotechnological interest

D Ribas, J Sá-Pessoa, I Soares-Silva… - FEMS Yeast …, 2017 - academic.oup.com
Sugar acids can be used as platform chemicals to generate primary building blocks of
industrially relevant products. Microbial production of these organic compounds at high …

Uncovering Novel Plasma Membrane Carboxylate Transporters in the Yeast Cyberlindnera jadinii

M Sousa-Silva, P Soares, J Alves, D Vieira, M Casal… - Journal of Fungi, 2022 - mdpi.com
The yeast Cyberlindnera jadinii has great potential in the biotechnology industry due to its
ability to produce a variety of compounds of interest, including carboxylic acids. In this work …

The Cryptococcus neoformans monocarboxylate transporter Jen4 is responsible for increased 3-bromopyruvate sensitivity

K Niedźwiecka, D Ribas, M Casal… - FEMS yeast …, 2019 - academic.oup.com
In the last decades, 3-bromopyruvate (3BP) has been intensively studied as a promising
anticancer and antimicrobial agent. The transport of this drug inside the cell is a critical step …