Particular features of diphtheria toxin internalization by resistant and sensitive mammalian cells

KY Manoilov, AJ Labyntsev, NV Korotkevych… - Cytology and …, 2018 - Springer
Several mammalian species are resistant to diphtheria toxin (DT). The DT receptor, proHB-
EGF in resistant and sensitive species, has a different primary structure due to the amino …

Biological properties and medical application of diphtheria toxin derivatives

KY Manoilov - Biotechnologia Acta, 2018 - cyberleninka.ru
The aim of the review was to analyze the literature data related to the application of a variety
of diphtheria toxin derivatives. Although the studies interaction with sensitive and resistant …

Necessity of translocation domain for realisation of cytostatic effect of non-toxic derivatives of diphtheria toxin

KY Manoilov, OI Krynina, LA Ju, SI Romaniuk… - Biotechnologia …, 2018 - cyberleninka.ru
The aim of the work was to evaluate in vitro the cytostatic effect of recombinant fragments of
the non-toxic point mutant of diphtheria toxin CRM197, which was suggested as a potent …

Характеризація очищеної рекомбінантної субодиниці В дифтерійного токсину як інструмента його дослідження

KY Manoilov, OB Gorbatiuk… - Reports of the …, 2017 - nasu-periodicals.org.ua
Очищення препаратів рекомбінантної субодиниці В (SbB) дифтерійного токсину (DT),
синтезованої в цитоплазмі, периплазмі і нерозчинних тільцях включення клітин …

Enhancement of internalization of diphtheria toxin recombinant fragments in sensitive cells mediated by toxin's T-domain

KY Manoilov, AJ Labyntsev… - The Ukrainian …, 2017 - irbis-nbuv.gov.ua
Subunit B of diphtheria toxin (DT) and its R-domain differ by the presence of T-domain. The
aim of the present work was to analyze the interaction of these toxin fragments with …

[引用][C] Biotechnologia Acta

KY Manoilov - Biotechnologia, 2018