Gene variants resulting in insertions or deletions of amino acid residues (indels) have
important consequences for evolution and are often linked to disease, yet, compared to …

A fundamental goal in evolutionary biology and population genetics is to understand how
selection shapes the fate of new mutations. Here, we test the null hypothesis that insertion …

The lipid phosphatase Ship2 interacts with the EphA2 receptor by forming a heterotypic Sam
(sterile alpha motif)–Sam complex. Ship2 works as a negative regulator of receptor …

Variants in the genes encoding gamma‐aminobutyric acid type A (GABAA) receptor
subunits are associated with epilepsy. To date, over 1000 clinical variants have been …

Measuring protein thermostability provides valuable information on the biophysical rules that
govern the structure-energy relationships of proteins. However, such measurements remain …

Amino acid deletions are high-risk, high-reward mutations, yet structural consequences are
poorly understood. In this issue of Structure, Woods et al.(2023) individually deleted 65 …

In this study, we evaluated a computational method combining AlphaFold2 (AF2) and
RosettaRelax (RR) to predict the impact of insertion and deletion (indel) mutations on the …

Measuring protein thermostability provides valuable information on the biophysical rules that
govern structure-energy relationships of proteins. However, such measurements remain a …