Psoriasis is a chronic, immune-mediated, inflammatory disease that is pathogenically driven
by proinflammatory cytokines. This article reviews the immunologic role of interleukin (IL)-17 …

Cytokines play a central role in the pathophysiology of autoimmune and inflammatory
diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized …

Background Many patients with psoriatic arthritis have an inadequate response to tumor
necrosis factor (TNF) inhibitors. Guselkumab, a specific inhibitor of interleukin-23 (IL-23) via …

Psoriasis vulgaris is a common, chronic inflammatory skin disease with a complex etiology
involving genetic risk factors and environmental triggers. Here we describe the many known …

STK11/LKB1 is among the most commonly inactivated tumor suppressors in non–small cell
lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many oncogenes …

Psoriatic arthritis (PsA), a heterogeneous chronic inflammatory immune-mediated disease
characterized by musculoskeletal inflammation (arthritis, enthesitis, spondylitis, and …

The discovery that the IL-23–IL-17 immune pathway is involved in many models of
autoimmune disease has changed the concept of the role of T-helper cell subsets in the …

NLRP3, a member of nucleotide-binding domain-(NOD) like receptor family, can be found in
large varieties of immune and non-immune cells. Upon activation, the NLRP3, apoptosis …

Background Guselkumab, a human monoclonal antibody that binds to the p19 subunit of
interleukin 23, has been approved for the treatment of moderate-to-severe psoriasis …

Abstract The interleukin-17 (IL-17) family consists of six family members (IL-17A–IL-17F) and
all the corresponding receptors have been identified recently. This family is mainly involved …