Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver
disease in the Western world, probably due to the growing prevalence of obesity, metabolic …

Increased hepatic glucose output, the primary liver dysregulation associated with Type 2
diabetes mellitus (T2DM), is not directly or effectively targeted by the currently available …

Transcriptionally mature and immature β-cells co-exist within the adult islet. How such
diversity contributes to insulin release remains poorly understood. Here we show that subtle …

Type 2 diabetes mellitus is a metabolic disorder with complicated pathogenesis, and mono-
target therapy often fails to effectively manage the levels of blood glucose. In recent years …

Mitochondria-associated endoplasmic reticulum membranes (MAM) play a key role in
mitochondrial dynamics and function and in hepatic insulin action. Whereas mitochondria …

Glucose metabolism in humans is tightly controlled by the activity of glucokinase (GCK).
GCK is predominantly produced in the pancreas, where it catalyzes the rate-limiting step of …

Modern nutrition is often characterized by the excessive intake of different types of
carbohydrates ranging from digestible polysaccharides to refined sugars that collectively …

Despite strong indications that increased consumption of added sugars correlates with
greater risks of developing cardiometabolic syndrome (CMS) and cardiovascular disease …

GCKR variants across the allelic spectrum have effects on glucose and lipid homeostasis.
Functional analysis has highlighted numerous molecular mechanisms for GKRP …

Glucokinase (GCK), a key enzyme in glucose metabolism, plays a central role in glucose
sensing and insulin secretion in pancreatic β-cells, as well as glycogen synthesis in the liver …