Deep learning-enabled realistic virtual histology with ultraviolet photoacoustic remote sensing microscopy

MT Martell, NJM Haven, BD Cikaluk, BS Restall… - Nature …, 2023 - nature.com
The goal of oncologic surgeries is complete tumor resection, yet positive margins are
frequently found postoperatively using gold standard H&E-stained histology methods …

Metabolic light absorption, scattering, and emission (MetaLASE) microscopy

BS Restall, NJM Haven, MT Martell, BD Cikaluk… - Science …, 2024 - science.org
Optical imaging of metabolism can provide key information about health and disease
progression in cells and tissues; however, current methods have lacked gold-standard …

Label-free complete absorption microscopy using second generation photoacoustic remote sensing

BR Ecclestone, K Bell, S Sparkes, D Dinakaran… - Scientific Reports, 2022 - nature.com
In the past decades, absorption modalities have emerged as powerful tools for label-free
functional and structural imaging of cells and tissues. Many biomolecules present unique …

Harnessing the power of optical microscopy for visualization and analysis of histopathological images

N Wang, C Zhang, X Wei, T Yan, W Zhou… - Biomedical Optics …, 2023 - opg.optica.org
Histopathology is the foundation and gold standard for identifying diseases, and precise
quantification of histopathological images can provide the pathologist with objective clues to …

Rapid ultraviolet photoacoustic remote sensing microscopy using voice-coil stage scanning

BD Cikaluk, BS Restall, NJM Haven, MT Martell… - Optics …, 2023 - opg.optica.org
There is an unmet need for fast virtual histology technologies that exhibit histological realism
and can scan large sections of fresh tissue within intraoperative time-frames. Ultraviolet …

Three-dimensional virtual histology in unprocessed resected tissues with photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT)

BR Ecclestone, Z Hosseinaee, N Abbasi, K Bell… - Scientific Reports, 2021 - nature.com
Histological images are critical in the diagnosis and treatment of cancers. Unfortunately,
current methods for capturing these microscopy images require resource intensive tissue …

Virtual histopathology with ultraviolet scattering and photoacoustic remote sensing microscopy

NJM Haven, MT Martell, BD Cikaluk, BS Restall… - Optics letters, 2021 - opg.optica.org
Realistic label-free virtual histopathology has been a long sought-after goal not yet achieved
with current methods. Here, we introduce high-resolution hematoxylin and eosin (H&E)-like …

Miniature non-contact photoacoustic probe based on fiber-optic photoacoustic remote sensing microscopy

J Zhou, J Zhou, W Wang, S Liang, L Jing, SH Bo… - Optics Letters, 2021 - opg.optica.org
Photoacoustic (PA) remote sensing (PARS) microscopy, featured by non-contact operation,
has shown great potential for PA microscopy (PAM) imaging applications. However, current …

Simultaneous deep ultraviolet transmission and scattering microscopy for virtual histology

BD Cikaluk, MH Masoumi, BS Restall, MT Martell… - Optics Letters, 2024 - opg.optica.org
In recent years, the emergence of a variety of novel optical microscopy techniques has
enabled the generation of virtual optical stains of unlabeled tissue specimens, which have …

Label-free virtual Hematoxylin and Eosin (H&E) staining using second generation Photoacoustic Remote Sensing (PARS)

BR Ecclestone, K Bell, S Sparkes, D Dinakaran… - arXiv preprint arXiv …, 2021 - arxiv.org
In the past decades, absorption modalities have emerged as powerful tools for label-free
functional and structural imaging of cells and tissues. Many biomolecules present unique …