Angiotensin Converting Enzyme2 is the cell surface binding site for the coronavirus SARS‐
CoV‐2, which causes COVID‐19. We propose that an imbalance in the action of ACE1‐and …

Nuclear factor κB (NF-κB) is a family of inducible transcription factors that plays a vital role in
different aspects of immune responses. NF-κB is normally sequestered in the cytoplasm as …

Cerebral small vessel disease (CSVD) causes dementia and gait disturbance due to
arteriopathy. Cerebral autosomal recessive arteriopathy with subcortical infarcts and …

Hypertension is the most common cause of left ventricular hypertrophy, contributing to heart
failure progression. Candesartan (Cand) is an angiotensin receptor antagonist widely used …

Cardiac fibrosis secondary to long‑term hypertension is known to promote cardiac
dysfunction; however, few therapeutic agents are available for the treatment of this condition …

Homeostasis in the cardiovascular system is maintained by physiological functions of the
Renin Angiotensin Aldosterone System (RAAS). In pathophysiological conditions, over …

Abstract Angiotensin II (Ang II) as an important pathogenic factor, has been implicated in the
pathogenesis of hypertension and associated renal injury, and inhibition of Ang II can …

Targeting the renin-angiotensin system and optimizing tacrolimus exposure are both
postulated to improve outcomes in renal transplant recipients (RTRs) by preventing …

Vascular hyperpermeability caused by distorted endothelial cell‐cell junctions is associated
with the no‐reflow phenomenon after opening of the occluded vessels in patients with …

Hypertension continues to be global pandemic with huge mortality, morbidity, and financial
burden on the health system. Unfortunately, most patients with hypertension would …