Background—This review article deals with the role of calcium in ischemic cell death. A
calcium-related mechanism was proposed more than two decades ago to explain cell …

Neurons are highly polarised, complex and incredibly energy intensive cells, and their
demand for ATP during neuronal transmission is primarily met by oxidative phosphorylation …

Chronic cerebral hypoperfusion is associated with vascular dementia (VaD). Cerebral
hypoperfusion may initiate complex molecular and cellular inflammatory pathways that …

Acute ischemic and brain injury is triggered by excitotoxic elevation of intraneuronal Ca2+
followed by reoxygenation-dependent oxidative stress, metabolic failure, and cell death …

Damage to the mitochondrial electron transport chain has been suggested to be an
important factor in the pathogenesis of a range of neurological disorders, such as …

A large body of evidence has appeared over the last 6 years suggesting that nitric oxide
biosynthesis is a key factor in the pathophysiological response of the brain to hypoxia …

The mechanisms which lead to secondary brain damage following transient ischaemia are
incompletely defined. As discussed in this hypothesis article, the events which lead to such …

Neurons are metabolically active cells that generally are dependent on mitochondrial A TP
production to meet their energetic needs. In contrast, other cell types with a high energy …

Recent in vitro cell-free studies have shown that cytochrome c release from mitochondria is
a critical step in the apoptotic process. The present study examined the expression of …

Free radicals are known to cause secondary neuronal damage in cerebral
ischemia/reperfusion (I/R). We investigated here the neuroprotective effect of resveratrol, a …