Applications of focused ultrasound in the brain: from thermoablation to drug delivery

Y Meng, K Hynynen, N Lipsman - Nature Reviews Neurology, 2021 - nature.com
Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …

Phase-change contrast agents for imaging and therapy

PS Sheeran, PA Dayton - Current pharmaceutical design, 2012 - ingentaconnect.com
Phase-change contrast agents (PCCAs) for ultrasound-based applications have resulted in
novel ways of approaching diagnostic and therapeutic techniques beyond what is possible …

Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles

NY Rapoport, AM Kennedy, JE Shea, CL Scaife… - Journal of Controlled …, 2009 - Elsevier
The paper reports the results of nanotherapy of ovarian, breast, and pancreatic cancerous
tumors by paclitaxel-loaded nanoemulsions that convert into microbubbles locally in tumor …

A super‐resolution ultrasound method for brain vascular mapping

MA OˈReilly, K Hynynen - Medical physics, 2013 - Wiley Online Library
Purpose: High‐resolution vascular imaging has not been achieved in the brain due to
limitations of current clinical imaging modalities. The authors present a method for …

Decafluorobutane as a phase-change contrast agent for low-energy extravascular ultrasonic imaging

PS Sheeran, VP Wong, S Luois, RJ McFarland… - Ultrasound in medicine …, 2011 - Elsevier
Currently available microbubbles used for ultrasound imaging and therapeutics are limited
to intravascular space due to their size distribution in the micron range. Phase-change …

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

K Hynynen, RM Jones - Physics in Medicine & Biology, 2016 - iopscience.iop.org
Focused ultrasound offers a non-invasive way of depositing acoustic energy deep into the
body, which can be harnessed for a broad spectrum of therapeutic purposes, including …

The role of inertial cavitation in acoustic droplet vaporization

ML Fabiilli, KJ Haworth, NH Fakhri… - IEEE transactions on …, 2009 - ieeexplore.ieee.org
The vaporization of a superheated droplet emulsion into gas bubbles using ultrasound-
termed acoustic droplet vaporization (ADV)-has potential therapeutic applications in …

Ultrasound in radiology: from anatomic, functional, molecular imaging to drug delivery and image-guided therapy

AL Klibanov, JA Hossack - Investigative radiology, 2015 - journals.lww.com
During the past decade, ultrasound has expanded medical imaging well beyond the
“traditional” radiology setting: a combination of portability, low cost, and ease of use makes …

Contrast-enhanced ultrasound imaging and in vivo circulatory kinetics with low-boiling-point nanoscale phase-change perfluorocarbon agents

PS Sheeran, JD Rojas, C Puett, J Hjelmquist… - Ultrasound in medicine …, 2015 - Elsevier
Many studies have explored phase-change contrast agents (PCCAs) that can be vaporized
by an ultrasonic pulse to form microbubbles for ultrasound imaging and therapy. However …

A review of numerical and experimental compensation techniques for skull-induced phase aberrations in transcranial focused ultrasound

A Kyriakou, E Neufeld, B Werner… - International journal …, 2014 - Taylor & Francis
The development of phased array transducers and their integration with magnetic
resonance (MR) guidance and thermal monitoring has established transcranial MR-guided …