Radiation‐induced normal tissue damage: oxidative stress and epigenetic mechanisms

J Wei, B Wang, H Wang, L Meng… - Oxidative medicine …, 2019 - Wiley Online Library
Radiotherapy (RT) is currently one of the leading treatments for various cancers; however, it
may cause damage to healthy tissue, with both short‐term and long‐term side effects …

Mechanisms of inflammatory responses to radiation and normal tissues toxicity: clinical implications

M Najafi, E Motevaseli, A Shirazi, G Geraily… - … journal of radiation …, 2018 - Taylor & Francis
Purpose: Cancer treatment is one of the most challenging diseases in the present era.
Among a few modalities for cancer therapy, radiotherapy plays a pivotal role in more than …

Radiation protection and mitigation by natural antioxidants and flavonoids: implications to radiotherapy and radiation disasters

R Yahyapour, D Shabeeb, M Cheki… - Current molecular …, 2018 - ingentaconnect.com
Background: Nowadays, ionizing radiations are used for various medical and terroristic
aims. These purposes involve exposure to ionizing radiations. Hence, people are at risk for …

The melatonin immunomodulatory actions in radiotherapy

M Najafi, A Shirazi, E Motevaseli, G Geraily… - Biophysical …, 2017 - Springer
Radiotherapy has a key role in cancer treatment in more than half of patients with cancer.
The management of severe side effects of this treatment modality is a limiting factor to …

Melatonin as an anti-inflammatory agent in radiotherapy

M Najafi, A Shirazi, E Motevaseli, AH Rezaeyan… - …, 2017 - Springer
Radiotherapy is one of the most relevant treatment options for cancer therapy with or without
other treatment modalities including immunotherapy, surgery and chemotherapy. Exposure …

COX-2 in radiotherapy: a potential target for radioprotection and radiosensitization

M Cheki, R Yahyapour, B Farhood… - Current Molecular …, 2018 - ingentaconnect.com
Background: Each year, millions of people die from cancer. Radiotherapy is one of the main
treatment strategies for cancer patients. Despite the beneficial roles of treatment with …

Hesperidin as radioprotector against radiation-induced lung damage in rat: a histopathological study

GH Haddadi, A Rezaeyan… - Journal of medical …, 2017 - journals.lww.com
Reactive oxygen species (ROS) are generated by ionizing radiation, and one of the organs
commonly affected by ROS is the lung. Radiation-induced lung injury including pneumonia …

Radiation-induced bystander phenomenon: insight and implications in radiotherapy

S Mukherjee, A Chakraborty - International journal of radiation …, 2019 - Taylor & Francis
Despite the extensive utilization of radiotherapy in cancer treatments, clinicians often face
challenges in achieving desired outcomes. This is because of the existence of secondary …

Melatonin ameliorates radiation-induced oxidative stress at targeted and nontargeted lung tissue

A Ghobadi, A Shirazi, M Najafi… - Journal of medical …, 2017 - journals.lww.com
Purpose: Radiation causes damage to irradiated tissues and also tissues that do not receive
direct irradiation through a phenomenon called out-of-field effects. This damage through …

Intercellular communications-redox interactions in radiation toxicity; potential targets for radiation mitigation

B Farhood, NH Goradel, K Mortezaee… - Journal of cell …, 2019 - Springer
Nowadays, using ionizing radiation (IR) is necessary for clinical, agricultural, nuclear energy
or industrial applications. Accidental exposure to IR after a radiation terror or disaster poses …