The term ferroptosis was coined in 2012 to describe an iron-dependent regulated form of
cell death caused by the accumulation of lipid-based reactive oxygen species; this type of …

Ferroptosis is a non-apoptotic form of cell death that can be triggered by small molecules or
conditions that inhibit glutathione biosynthesis or the glutathione-dependent antioxidant …

Ferroptosis is form of regulated nonapoptotic cell death that is involved in diverse disease
contexts. Small molecules that inhibit glutathione peroxidase 4 (GPX4), a phospholipid …

Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Vitamin K is an essential bioactive compound required for optimal body function. Vitamin K
can be present in various isoforms, distinguishable by two main structures, namely …

The global diabetes epidemic and its complications are increasing, thereby posing a major
threat to public health. A comprehensive understanding of diabetes mellitus (DM) and its …

Brain injury in the premature infant, a problem of enormous importance, is associated with a
high risk of neurodevelopmental disability. The major type of injury involves cerebral white …

Ferroptosis is an iron-dependent cell death, which is characterized by iron overload and
lipid peroxidation. Ferroptosis is distinct from apoptosis, necroptosis, autophagy, and other …

Lipoxygenases (LOX) form a family of lipid peroxidizing enzymes, which have been
implicated in a number of physiological processes and in the pathogenesis of inflammatory …

Significance: Glutathione (GSH) depletion is a central signaling event that regulates the
activation of cell death pathways. GSH depletion is often taken as a marker of oxidative …