Breaking the chains: deubiquitylating enzyme specificity begets function
The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …
Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response
NA Snyder, GM Silva - Journal of Biological Chemistry, 2021 - ASBMB
Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …
Mechanisms of deubiquitinase specificity and regulation
TET Mevissen, D Komander - Annual review of biochemistry, 2017 - annualreviews.org
Protein ubiquitination is one of the most powerful posttranslational modifications of proteins,
as it regulates a plethora of cellular processes in distinct manners. Simple …
as it regulates a plethora of cellular processes in distinct manners. Simple …
[HTML][HTML] The ESCRT pathway
WM Henne, NJ Buchkovich, SD Emr - Developmental cell, 2011 - cell.com
Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or
lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key …
lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key …
The demographics of the ubiquitin system
The ubiquitin system is a major coordinator of cellular physiology through regulation of both
protein degradation and signalling pathways. A key building block of a systems-level …
protein degradation and signalling pathways. A key building block of a systems-level …
Breaking the chains: structure and function of the deubiquitinases
Ubiquitylation is a reversible protein modification that is implicated in many cellular
functions. Recently, much progress has been made in the characterization of a superfamily …
functions. Recently, much progress has been made in the characterization of a superfamily …
Endocytosis of receptor tyrosine kinases
LK Goh, A Sorkin - Cold Spring Harbor perspectives in …, 2013 - cshperspectives.cshlp.org
Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The
canonical model of RTK endocytosis involves rapid internalization of an RTK activated by …
canonical model of RTK endocytosis involves rapid internalization of an RTK activated by …
Deubiquitylases from genes to organism
Ubiquitylation is a major posttranslational modification that controls most complex aspects of
cell physiology. It is reversed through the action of a large family of deubiquitylating …
cell physiology. It is reversed through the action of a large family of deubiquitylating …
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
C Raiborg, H Stenmark - Nature, 2009 - nature.com
Selective trafficking of membrane proteins to lysosomes for destruction is required for proper
cell signalling and metabolism. Ubiquitylation aids this process by specifying which proteins …
cell signalling and metabolism. Ubiquitylation aids this process by specifying which proteins …
Feedback regulation of EGFR signalling: decision making by early and delayed loops
R Avraham, Y Yarden - Nature reviews Molecular cell biology, 2011 - nature.com
Human-made information relay systems invariably incorporate central regulatory
components, which are mirrored in biological systems by dense feedback and feedforward …
components, which are mirrored in biological systems by dense feedback and feedforward …