The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …

Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …

Protein ubiquitination is one of the most powerful posttranslational modifications of proteins,
as it regulates a plethora of cellular processes in distinct manners. Simple …

Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or
lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key …

The ubiquitin system is a major coordinator of cellular physiology through regulation of both
protein degradation and signalling pathways. A key building block of a systems-level …

Ubiquitylation is a reversible protein modification that is implicated in many cellular
functions. Recently, much progress has been made in the characterization of a superfamily …

Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The
canonical model of RTK endocytosis involves rapid internalization of an RTK activated by …

Ubiquitylation is a major posttranslational modification that controls most complex aspects of
cell physiology. It is reversed through the action of a large family of deubiquitylating …

Selective trafficking of membrane proteins to lysosomes for destruction is required for proper
cell signalling and metabolism. Ubiquitylation aids this process by specifying which proteins …

Human-made information relay systems invariably incorporate central regulatory
components, which are mirrored in biological systems by dense feedback and feedforward …