Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …

The identification of extracellular phospholipid vesicles as conveyors of cellular information
has created excitement in the field of drug delivery. Biological therapeutics, including short …

To achieve therapeutic success, transfer vehicles for gene therapy must be capable of
transducing target cells while avoiding impact on non-target cells. Despite the high …

During the past decade, RGD-peptides have become a popular tool for the targeting of
drugs and imaging agents to αvβ3-integrin expressing tumour vasculature. RGD-peptides …

Adenoviral (Ad) vectors have emerged as a promising gene delivery platform for a variety of
therapeutic and vaccine purposes during last two decades. However, the presence of …

Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is a
fundamental process during cancer progression. Anti-angiogenic strategies have been …

The chemical modification of adenovirus (Ad) gene transfer vectors with synthetic polymers
is a promising strategy for overcoming typical in vivo hurdles associated with Ad-mediated …

Hyperthermia can be produced by near-infrared laser irradiation of gold nanoparticles
present in tumors and thus induce tumor cell killing via a bystander effect. To be clinically …

Peptide/protein− synthetic polymer conjugates, which covalently combine one or more
copies of a peptide sequence or protein with one or more synthetic polymer elements, offer …

Targeted delivery strategies are becoming increasingly important. Herein, a novel
hyperbranched amphiphilic poly [(amine-ester)-co-(d, l-lactide)]/1, 2-dipalmitoyl-sn-glycero-3 …